| ○種別 (必須): |
| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Komohara Yoshihiro (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Takemura Kenichi (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Lei Feng Xiao (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | 坂下 直実
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Harada Mamoru (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Suzuki Hiroshi (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Kodama Tatsuhiko (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Takeya Motohiro (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Class A scavenger receptors (SR-A, CD204) are highly expressed in tumor-associated macrophages (TAM). To investigate the function of SR-A in TAM, wild-type and SR-A-deficient (SR-A(-/-)) mice were injected with EL4 cells. Although these groups of mice did not differ in the numbers of infiltrating macrophages and lymphocytes and in neovascularization, SR-A(-/-) mice had delayed growth of EL4 tumors. Expression of inducible nitric oxide (NO) synthase and interferon (IFN)-gamma mRNA increased significantly in tumor tissues from SR-A(-/-) mice. Engulfment of necrotic EL4 cells induced upregulation of NO and IFN-gamma production by cultured macrophages, and production of NO and IFN-gamma increased in SR-A(-/-) macrophages in vitro. IFN-beta production by cultured macrophages was also elevated in SR-A(-/-) macrophages in vitro. These results suggested that the antitumor activity of macrophages increased in SR-A(-/-) mice because of upregulation of NO and IFN-gamma production. These data indicate an important role of SR-A in regulating TAM function by inhibiting toll-like receptor (TLR)4-IFN-beta signaling. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | アポトーシス (apoptosis)
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| 3. | (英) Cell Proliferation (日) (読)
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| 4. | 細胞質分裂 (cytokinesis)
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| 5. | (英) Interferon-gamma (日) (読)
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| 6. | (英) Lymphoma (日) (読)
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| 7. | (英) Macrophages (日) (読)
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| 8. | (英) Mice (日) (読)
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| 9. | (英) Mice, Inbred C57BL (日) (読)
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| 10. | 一酸化窒素 (nitric oxide)
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| 11. | (英) RNA, Messenger (日) (読)
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| 12. | (英) Scavenger Receptors, Class A (日) (読)
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| 13. | (英) Up-Regulation (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Cancer Science ([日本癌学会])
(pISSN: 1347-9032, eISSN: 1349-7006)
| ○ISSN (任意): | □ | 1349-7006
ISSN: 1347-9032
(pISSN: 1347-9032, eISSN: 1349-7006) Title: Cancer scienceTitle(ISO): Cancer SciPublisher: Wiley-Blackwell (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 100
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| ○号 (必須): | □ | 11
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| ○頁 (必須): | □ | 2160 2166
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2009年 7月 23日 (平成 21年 7月 23日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/j.1349-7006.2009.01296.x (→Scopusで検索)
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| ○PMID (任意): | □ | 19694752 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-71049140879
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1111/j.1349-7006.2009.01296.x (日)
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| 2. | (英) Article.Affiliation: Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Japan. (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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