| ○種別 (必須): |
| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Komohara Yoshihiro (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Hirahara Junko (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Horikawa Tomohiro (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Kawamura Kyoko (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Kiyota Emi (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | 坂下 直実
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Araki Norie (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Takeya Motohiro (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) AM-3K, an anti-macrophage antibody, recognizes CD163, a molecule associated with an anti-inflammatory macrophage phenotype. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) CD163 is a member of the scavenger receptor cysteine-rich superfamily restricted to the monocyte/macrophage lineage and is thought to be a useful marker for anti-inflammatory or alternatively activated macrophages. In this study we used mass spectrometric analysis to determine that the antigen recognized by the antibody AM-3K, which we previously generated as a tissue macrophage-specific monoclonal antibody, was CD163. An anti-inflammatory subtype of macrophages stimulated by dexamethasone or interleukin-10 showed strong reactivity for AM-3K and increased expression of CD163 mRNA. Immunohistochemical staining of routinely processed pathological specimens revealed that AM-3K recognized a specialized subpopulation of macrophages. In granulomatous diseases such as tuberculosis, sarcoidosis, or foreign body reactions, tissue macrophages around granulomas, but not component cells of the granulomas such as epithelioid cells and multinucleated giant cells, showed positive staining for AM-3K. In atherosclerotic lesions, scattered macrophages in diffuse intimal lesions were strongly positive for AM-3K, whereas foamy macrophages in atheromatous plaques demonstrated only weak staining. We therefore suggest that, in routine pathological specimens, AM-3K is a useful marker for anti-inflammatory macrophages because these cells can be distinguished from inflammatory or classically activated macrophages. Because AM-3K cross-reacts with macrophage subpopulations in different animal species including rats, guinea pigs, rabbits, cats, dogs, goats, pigs, bovine species, horses, monkeys, and cetaceans, it will have wide application for detection of CD163 in various animals. (日)
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| ○キーワード (推奨): | 1. | (英) Antigens, CD (日) (読)
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| 2. | (英) Antigens, Differentiation, Myelomonocytic (日) (読)
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| 3. | 動脈硬化 (atherosclerosis)
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| 4. | (英) Bone Neoplasms (日) (読)
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| 5. | 細胞分化 (cell differentiation)
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| 6. | (英) Electrophoresis, Polyacrylamide Gel (日) (読)
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| 7. | (英) Foreign-Body Reaction (日) (読)
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| 8. | (英) Gaucher Disease (日) (読)
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| 9. | (英) Giant Cell Tumors (日) (読)
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| 10. | (英) Histiocytosis, Non-Langerhans-Cell (日) (読)
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| 11. | (英) Histiocytosis, Sinus (日) (読)
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| 12. | (英) Humans (日) (読)
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| 13. | 免疫組織化学 (immunohistochemistry)
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| 14. | (英) Macrophage Activation (日) (読)
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| 15. | (英) Macrophages (日) (読)
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| 16. | 質量分析法 (mass spectrometry)
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| 17. | (英) Paraffin Embedding (日) (読)
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| 18. | (英) Phenotype (日) (読)
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| 19. | (英) Receptors, Cell Surface (日) (読)
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| 20. | (英) Sarcoidosis (日) (読)
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| 21. | (英) Soft Tissue Neoplasms (日) (読)
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| 22. | (英) Synovial Membrane (日) (読)
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| 23. | (英) Tuberculosis, Pulmonary (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Histochemistry and Cytochemistry (The Histochemical Society)
(pISSN: 0022-1554, eISSN: 1551-5044)
| ○ISSN (任意): | □ | 0022-1554
ISSN: 0022-1554
(pISSN: 0022-1554, eISSN: 1551-5044) Title: The journal of histochemistry and cytochemistry : official journal of the Histochemistry SocietyTitle(ISO): J Histochem CytochemPublisher: Histochemical Society (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 54
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | 763 771
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2006年 3月 3日 (平成 18年 3月 3日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1369/jhc.5A6871.2006 (→Scopusで検索)
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| ○PMID (任意): | □ | 16517975 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-33745410678
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University 1-1-1, Honjo Kumamoto, Kumamoto 860-8556, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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