『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=269094EID:269094, Map:0, LastModified:2014年3月3日(月) 10:56:56, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[岡村 裕彦], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座.口腔組織学 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1.岡村 裕彦
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[継承]
2.吉田 賀弥 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健教育学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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[継承]
3.楊 諦
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[継承]
4.羽地 達次
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[継承]
題名 (必須): (英) Protein phosphatase 2A Cα regulates osteoblast differentiation and the expressions of bone sialoprotein and osteocalcin via osterix transcription factor.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Serine/threonine protein phosphatase 2A (PP2A) participates in regulating many important physiological processes such as cell cycle, growth, apoptosis, and signal transduction. Osterix is a zinc-finger-containing transcription factor that is essential for osteoblast differentiation and regulation of many bone-related genes. We have recently reported that decrease in α-isoform of PP2A catalytic subunit (PP2A Cα) accelerates osteoblast differentiation through the expression of bone-related genes. In this study, we further examined the role of PP2A Cα in osteoblast differentiation by establishing the stable cell lines that overexpress PP2A Cα. Overexpression of PP2A Cα reduced alkaline phosphatase (ALP) activity. Osteoblast differentiation and mineralization were also decreased in PP2A Cα-overexpressing cells, with reduction of bone-related genes including osterix, bone sialoprotein (Bsp), and osteocalcin (OCN). Luciferase assay showed that the transcriptional activity of the Osterix promoter region was decreased in PP2A Cα-overexpressing cells. Introduction of ectopic Osterix rescued the expression of Bsp and OCN in PP2A Cα-overexpressing cells. These results indicate that PP2A Cα and its activity play a negative role in osteoblast differentiation and Osterix is a key factor responsible for regulating the expressions of Bsp and OCN during PP2A Cα-mediated osteoblast differentiation.  (日)    [継承]
キーワード (推奨): 1.骨芽細胞 (osteoblast) [継承]
2.プロテインフォスファターゼ (protein phosphatase) [継承]
発行所 (推奨):
誌名 (必須): Journal of Cellular Physiology ([Wiley-Liss, Inc.])
(pISSN: 0021-9541, eISSN: 1097-4652)

ISSN (任意): 1097-4652
ISSN: 0021-9541 (pISSN: 0021-9541, eISSN: 1097-4652)
Title: Journal of cellular physiology
Title(ISO): J Cell Physiol
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 228 [継承]
(必須): 5 [継承]
(必須): 1031 1037 [継承]
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年月日 (必須): 西暦 2013年 5月 初日 (平成 25年 5月 初日) [継承]
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DOI (任意): 10.1002/jcp.24250    (→Scopusで検索) [継承]
PMID (任意): 23042641    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1002/jcp.24250  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hirohiko Okamura, Kaya Yoshida, Di Yang and Tatsuji Haneji : Protein phosphatase 2A Cα regulates osteoblast differentiation and the expressions of bone sialoprotein and osteocalcin via osterix transcription factor., Journal of Cellular Physiology, Vol.228, No.5, 1031-1037, 2013.
欧文冊子 ● Hirohiko Okamura, Kaya Yoshida, Di Yang and Tatsuji Haneji : Protein phosphatase 2A Cα regulates osteoblast differentiation and the expressions of bone sialoprotein and osteocalcin via osterix transcription factor., Journal of Cellular Physiology, Vol.228, No.5, 1031-1037, 2013.

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