『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=268914EID:268914, Map:0, LastModified:2014年1月27日(月) 14:29:15, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[吉田 賀弥], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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学究種別 (推奨):
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著者 (必須): 1. (英) Makoto Ishikawa (日) 石川 真琴 (読) いしかわ まこと
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2.吉田 賀弥 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健教育学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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3.岡村 裕彦
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4.落合 和彦
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5. (英) Haruna Takamura (日) 高村 春菜 (読) たかむら はるな
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6.藤原 奈津美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学])
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7.尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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題名 (必須): (英) Oral porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3b signaling pathway  (日)    [継承]
副題 (任意):
要約 (任意): (英) Periodontal diseases are common chronic inflammatory disorders that result in the destruction of tissues around teeth. Many clinical studies suggest that periodontal diseases are risk factors for insulin resistance and diabetic mellitus development. However, the molecular mechanisms by which periodontal diseases regulate the progress of diabetes mellitus remain unknown. In this study, we investigated whether Porphyromonas gingivalis (P.g.), a major pathogen of periodontal diseases, present in the oral cavity, moves to the liver and affects hepatic glycogen synthesis. SNAP26b-tagged P.g. (SNAP-P.g.) was introduced into the oral cavity to induce periodontal disease in 4-week old female Balb/c mice. SNAP-P.g. was detected in the liver extracted from SNAP-P.g.-treated mice using nested PCR analysis. High blood glucose levels tended to promote SNAP-P.g. translocation from the oral cavity to the liver in mice. Periodic acid-Schiff staining suggested that hepatic glycogen synthesis decreased in SNAP-P.g.-treated mice. SNAP-P.g. was also internalized into the human hepatoma cell line HepG2, and this attenuated the phosphorylation of insulin receptor substrate (IRS)-1, Akt and glycogen synthase kinase-3β induced by insulin. Insulin-induced glycogen synthesis was suppressed by SNAP-P.g. in HepG2 cells. Our results suggest that P.g. translocation from the oral cavity to the liver may contribute to the progress of diabetes mellitus by influencing hepatic glycogenesis.  (日)    [継承]
キーワード (推奨): 1.歯周炎 (periodontal disease) [継承]
2.糖尿病 (diabetes mellitus) [継承]
3. (英) Porphyromonas gingivalis (日) (読) [継承]
4. (英) Hepatic glycogenesis (日) (読) [継承]
5. (英) SNAP26b (日) (読) [継承]
発行所 (推奨): Elsevier Science [継承]
誌名 (必須): Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ([Elsevier Science])
(pISSN: 0925-4439)

ISSN (任意): 0925-4439
ISSN: 0925-4439 (pISSN: 0925-4439, eISSN: 1879-260X)
Title: Biochimica et biophysica acta. Molecular basis of disease
Title(ISO): Biochim Biophys Acta Mol Basis Dis
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1832 [継承]
(必須): 12 [継承]
(必須): 2035 2043 [継承]
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年月日 (必須): 西暦 2013年 12月 初日 (平成 25年 12月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/j.bbadis.2013.07.012    (→Scopusで検索) [継承]
PMID (任意): 23899607    (→Scopusで検索) [継承]
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WOS (任意): 000327567600014 [継承]
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備考 (任意): 1.(英) Article.ELocationID: S0925-4439(13)00255-X  (日)    [継承]
2.(英) Article.ELocationID: 10.1016/j.bbadis.2013.07.012  (日)    [継承]
3.(英) Article.Affiliation: Department of Oral Healthcare Promotion, The University of Tokushima Graduate School, Kuramoto, Tokushima 770-8504, Japan.  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: JOURNAL ARTICLE  (日)    [継承]
5.(英) KeywordList.Keyword: Diabetes mellitus  (日)    [継承]
6.(英) KeywordList.Keyword: Hepatic glycogenesis  (日)    [継承]
7.(英) KeywordList.Keyword: Periodontal disease  (日)    [継承]
8.(英) KeywordList.Keyword: Porphyromonas gingivalis  (日)    [継承]
9.(英) KeywordList.Keyword: SNAP26b  (日)    [継承]

標準的な表示

和文冊子 ● Ishikawa Makoto, Kaya Yoshida, Hirohiko Okamura, Kazuhiko Ochiai, Takamura Haruna, Natsumi Fujiwara and Kazumi Ozaki : Oral porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3b signaling pathway, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol.1832, No.12, 2035-2043, 2013.
欧文冊子 ● Ishikawa Makoto, Kaya Yoshida, Hirohiko Okamura, Kazuhiko Ochiai, Takamura Haruna, Natsumi Fujiwara and Kazumi Ozaki : Oral porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3b signaling pathway, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol.1832, No.12, 2035-2043, 2013.

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