| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 河野 崇
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| 2. | (英) Yamazaki Fumimoto (日) 山崎 史幹 (読)
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| 3. | 川人 伸次 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
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| 4. | 江口 覚 ([徳島大学.病院.診療科.歯科口腔外科.歯科麻酔科])
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| ○題名 (必須): | □ | (英) Dexmedetomidine directly inhibits vascular ATP-sensitive potassium channels. (日)
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| ○要約 (任意): | □ | (英) Dexmedetomidine is reported to have an effect on peripheral vasoconstriction; however, the exact mechanisms underlying this process are unclear. In this study, we hypothesized that dexmedetomidine-induced inhibition of vascular ATP-sensitive K(+) (K(ATP)) channels may be associated with this vasoconstriction. To test this hypothesis, we investigated the effects of dexmedetomidine on vascular K(ATP)-channel activity at the single-channel level. We used cell-attached and inside-out patch-clamp configurations to examine the effects of dexmedetomidine on the activities of native rat vascular K(ATP) channels, recombinant K(ATP) channels with different combinations of various inwardly rectifying potassium channels (Kir6.0 family: Kir6.1, 6.2) and sulfonylurea receptor subunits (SUR1, 2A, 2B), and SUR-deficient channels derived from a truncated isoform of Kir6.2 subunit, namely, Kir6.2ΔC36 channels. Dexmedetomidine was observed to inhibit the native rat vascular K(ATP) channels in both cell-attached and inside-out configurations. This drug also inhibited the activity of all types of recombinant SUR/Kir6.0 K(ATP) channels as well as Kir6.2ΔC36 channels with equivalent potency. These results indicate that dexmedetomidine directly inhibits K(ATP) channels through the Kir6.0 subunit. (日)
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| ○キーワード (推奨): | 1. | (英) Adrenergic alpha-2 Receptor Agonists (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Aorta (日) (読)
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| 4. | (英) Dexmedetomidine (日) (読)
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| 5. | (英) KATP Channels (日) (読)
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| 6. | (英) Male (日) (読)
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| 7. | (英) Rats (日) (読)
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| 8. | (英) Rats, Wistar (日) (読)
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| 9. | (英) Recombinant Proteins (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Life Sciences ([Elsevier])
(pISSN: 0024-3205, eISSN: 1879-0631)
| ○ISSN (任意): | □ | 1879-0631
ISSN: 0024-3205
(pISSN: 0024-3205, eISSN: 1879-0631) Title: Life sciencesTitle(ISO): Life SciPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 90
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| ○号 (必須): | □ | 7-8
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| ○頁 (必須): | □ | 272 277
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2012年 2月 初日 (平成 24年 2月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.lfs.2011.11.009 (→Scopusで検索)
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| ○PMID (任意): | □ | 22155038 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.lfs.2011.11.009 (日)
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| 2. | (英) Article.Affiliation: Department of Anesthesiology and Critical Care Medicine, Kochi Medical School, Kochi, Japan. takashika@kochi-u.ac.jp (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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