| ○種別 (必須): |
| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 酒井 紀典 ([徳島大学.病院.中央診療施設等.高度先進整形外科診療部])
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| 2. | (英) Eskander N. Ramez (日) (読)
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| 3. | (英) Guo Yi (日) (読)
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| 4. | (英) Kim Jung Kap (日) (読)
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| 5. | (英) Mefford Jason (日) (読)
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| 6. | (英) Hopkins Justin (日) (読)
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| 7. | (英) Bhatia N. Nitin (日) (読)
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| 8. | (英) Zi Xiaolin (日) (読)
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| 9. | (英) Hoang H. Bang (日) (読)
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| ○題名 (必須): | □ | (英) Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines. (日)
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| ○要約 (任意): | □ | (英) Synovial sarcomas (SS) are soft tissue sarcomas with poor prognosis, displaying a lack of response to conventional cytotoxic chemotherapy. Although SS cell lines have moderate chemosensitivity to isofamide and doxorubicin therapy, the clinical prognosis is still poor. In this article, we showed that flavokawain B (FKB), a novel chalcone from kava extract, potently inhibits the growth of SS cell lines SYO-I and HS-SY-II through induction of apoptosis. Treatment with FKB increased caspase 8, 9, and 3/7 activity compared to vehicle-treated controls, indicating that both extrinsic and intrinsic apoptotic pathways were activated. Furthermore, FKB treatment of both cell lines resulted in increased mRNA and protein expression of death receptor-5 and the mitochondrial pro-apoptotic proteins Bim and Puma, while down-regulating the expression of an inhibitor of apoptosis, survivin in a dose-dependent manner. Our results suggest the natural compound FKB has a pro-apoptotic effect on SS cell lines. FKB may be a new chemotherapeutic strategy for patients with SS and deserves further investigation as a potential agent in the treatment of this malignancy. (日)
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| ○キーワード (推奨): | 1. | (英) Antineoplastic Agents, Phytogenic (日) (読)
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| 2. | (英) Apoptosis (日) (読)
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| 3. | (英) Apoptosis Regulatory Proteins (日) (読)
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| 4. | (英) Cell Line, Tumor (日) (読)
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| 5. | (英) Chalcone (日) (読)
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| 6. | (英) Endometrium (日) (読)
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| 7. | (英) Female (日) (読)
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| 8. | (英) Fibroblasts (日) (読)
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| 9. | (英) Flavonoids (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | (英) Inhibitor of Apoptosis Proteins (日) (読)
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| 12. | (英) Kava (日) (読)
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| 13. | (英) Membrane Proteins (日) (読)
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| 14. | (英) Proto-Oncogene Proteins (日) (読)
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| 15. | (英) Receptors, TNF-Related Apoptosis-Inducing Ligand (日) (読)
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| 16. | (英) Sarcoma, Synovial (日) (読)
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| 17. | (英) Soft Tissue Neoplasms (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Orthopaedic Research (Bioelectric Repair and Growth Society/Orthopaedic Research Society)
(pISSN: 0736-0266, eISSN: 1554-527X)
| ○ISSN (任意): | □ | 1554-527X
ISSN: 0736-0266
(pISSN: 0736-0266, eISSN: 1554-527X) Title: Journal of orthopaedic research : official publication of the Orthopaedic Research SocietyTitle(ISO): J Orthop ResSupplier: Orthopaedic Research SocietyPublisher: Wiley (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 30
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | 1045 1050
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2011年 12月 29日 (平成 23年 12月 29日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1002/jor.22050 (→Scopusで検索)
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| ○PMID (任意): | □ | 22213202 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1002/jor.22050 (日)
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| 2. | (英) Article.Affiliation: Department of Orthopaedic Surgery, University of California Irvine, 101 The City Drive South, Orange, California 92868, USA. (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: In Vitro (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 5. | (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural (日)
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| 6. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 7. | (英) OtherID: NIHMS481620 (日)
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| 8. | (英) OtherID: PMC3685290 (日)
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