『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.堀口 英久
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2. (英) Sumiyo Yamagata (日) 山形 寿美代 (読) やまがた すみよ
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3.銭 志栄
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4.香川 聖子
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5.坂下 直実
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題名 (必須): (英) Thrombospondin-1 is highly expressed in desmoplstic components of invasive ductal carcinoma of the breast and associated with ,ymph node metastasis  (日)    [継承]
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要約 (任意): (英) Desmoplastic (scirrhous) invasion and lymph node metastasis are critical for the treatment and prognosis of invasive ductal carcinoma of the breast. Despite being an anti-angiogenic therapeutic candidate, Thrombospondin-1 (TSP-1) promotes invasion and metastasis of some carcinomas. To clarify the effect of TSP-1 on invasion and metastasis, we obtained 101 invasive ductal carcinomas of the breast with axillary lymph node resection. All tumors were histologically divided into two categories, carcinomas with, and those with non- /minimal desmoplastic component. Immunohistochemistry for TSP-1 was performed on all primary tumors and axillary lymph nodes with tumor metastasis. Fifty-four (53.5%) of 101 tumors were recognized as positive for TSP-1 in the cytoplasm of tumor cells. Histological study showed that significantly more cancers with desmoplastic components (46/69, 66.7%) manifested TSP-1 expression than did cancers with no- or minimal (less than 20%) desmoplasia (8/32, 25.0%; p<0.001). Axillary lymph node metastasis was significantly higher in TSP-1-positive- (28/54, 51.9%) than TSP-1-negative cancers (11/47, 23.4%; p<0.005). The present study indicates that tumor cells in the desmoplastic component strongly expressed TSP-1 in invasive ductal carcinoma of the breast and TSP-1 participates in invasion of these tumors. Our findings also suggest that TSP-1 promotes lymph node metastasis and TSP-1 potentially could be a predictive marker for metastasis.  (日)    [継承]
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誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2013年 2月 初日 (平成 25年 2月 初日) [継承]
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DOI (任意): 10.2152/jmi.60.91    (→Scopusで検索) [継承]
PMID (任意): 23614916    (→Scopusで検索) [継承]
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機関リポジトリ : 111303 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

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和文冊子 ● Hidehisa Horiguchi, Yamagata Sumiyo, Zhi-Rong Qian, Seiko Kagawa and Naomi Sakashita : Thrombospondin-1 is highly expressed in desmoplstic components of invasive ductal carcinoma of the breast and associated with ,ymph node metastasis, The Journal of Medical Investigation : JMI, Vol.60, No.1, 2, 91-96, 2013.
欧文冊子 ● Hidehisa Horiguchi, Yamagata Sumiyo, Zhi-Rong Qian, Seiko Kagawa and Naomi Sakashita : Thrombospondin-1 is highly expressed in desmoplstic components of invasive ductal carcinoma of the breast and associated with ,ymph node metastasis, The Journal of Medical Investigation : JMI, Vol.60, No.1, 2, 91-96, 2013.

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