| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Ichiyanagi Takashi (日) (読)
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| 2. | 柏田 良樹
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| 3. | (英) Shida Yasuo (日) (読)
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| 4. | (英) Sekiya Michiko (日) (読)
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| 5. | (英) Hatano Yoshihiko (日) (読)
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| 6. | 高石 喜久 ([徳島大学.デザイン型AI教育研究センター])
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| 7. | (英) Ikeshiro Yasumasa (日) (読)
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| ○題名 (必須): | □ | (英) Structural elucidation and biological fate of two glucuronyl metabolites of pelargonidin 3-O--D-glucopyranoside in rats. (日)
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| ○要約 (任意): | □ | (英) A high proportion of pelargonidin 3-O--D-glucopyranoside (Pg3G) is metabolized to glucuronides and excreted in mammal urine after ingestion of strawberry fruit, suggesting that these metabolites play important functional roles in vivo. The aim of the present study was to elucidate the structures and determine the biological fate of the two dominant metabolites of Pg3G in rats to enable an accurate discussion of the biological properties of anthocyanins. Authentic Pg3G was orally administered to rats. One pelargonidin monoglucuronide and three Pg3G-monoglucuronides (glucuronides of the glucoside) were identified together with intact Pg3G in both blood plasma and urine samples. The structures of the two dominant metabolites were elucidated as pelargonidin 3-O--D-glucuronide (Pg3GlcA) and pelargonidin 3-O--D-glucuronyl-(12)--D-glucoside by means of (1)H and (13)C nuclear magnetic resonance spectroscopy and heteronuclear multiple-bond connective spectroscopy. The bioavailability of Pg3G in its intact form was 0.31% of the orally administered dose, and 0.65% was absorbed in the Pg3GlcA form. (日)
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| ○誌名 (必須): | □ | Journal of Agricultural and Food Chemistry ([アメリカ化学会])
(pISSN: 0021-8561, eISSN: 1520-5118)
| ○ISSN (任意): | □ | 1520-5118
ISSN: 0021-8561
(pISSN: 0021-8561, eISSN: 1520-5118) Title: Journal of agricultural and food chemistryTitle(ISO): J Agric Food ChemPublisher: American Chemical Society (NLM Catalog)
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| ○巻 (必須): | □ | 61
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 569 578
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2013年 1月 9日 (平成 25年 1月 9日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1021/jf3032793 (→Scopusで検索)
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| ○PMID (任意): | □ | 23256460 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1021/jf3032793 (日)
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| 2. | (英) Article.Affiliation: Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Akiha-ku, Niigata, Japan. ichiyanagi@niit.ac.jp (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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