『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=266134)

EID=266134EID:266134, Map:0, LastModified:2013年8月2日(金) 09:59:58, Operator:[田中 栄二], Avail:TRUE, Censor:0, Owner:[田中 栄二], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.顎口腔再建医学講座.口腔顎顔面矯正学 (2004年4月1日〜2015年3月31日) [継承]
2.徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学 (2004年4月1日〜) [継承]
3.徳島大学.病院.診療科.矯正歯科 (2003年10月1日〜) [継承]
著者 (必須): 1.米田 尚子 ([徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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学籍番号 (推奨):
[継承]
2.泰江 章博
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[継承]
3.渡邉 哲平 ([徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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[継承]
4.田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Down-regulation of Smad3 Accelerates Palatal Wound Repair.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Smad3-deficient mice exhibit accelerated re-epithelialization and tissue remodeling during palatal wound repair. In addition, transforming growth factor beta 1 (TGF-1) and other inflammatory factors are down-regulated compared with those in wild-type mice. The aim of this study was to examine whether targeting of Smad3 with small interfering RNA (siRNA) accelerates wound-healing and inhibits wound contraction in palatal mucoperiosteal wounds. An initial histological examination of wound closure in mouse palates treated with Smad3-targeted siRNA vs. a scrambled siRNA found that wound-healing was accelerated when levels of Smad3 were decreased. Furthermore, with real-time PCR, mRNA levels of Smad3, TGF-1, monocyte chemotactic protein-1 (MCP-1), and macrophage inflammatory protein-1 (MIP-1) were found to be significantly down-regulated in palatal tissue treated with Smad3-targeted siRNA vs. a control siRNA. Protein and mRNA levels of -smooth-muscle actin (-SMA), type I collagen, and fibronectin were also lower in palates treated with Smad3-targeted siRNA vs. control siRNA. Taken together, these results indicate that down-regulation of Smad3 expression by siRNA can accelerate wound-healing and may inhibit wound contraction. Therefore, siRNA-targeted inhibition of Smad3 may represent a valuable therapeutic tool for palatal mucoperiosteal wound-healing.  (日)    [継承]
キーワード (推奨):
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誌名 (必須): Journal of Dental Research ([国際歯科研究学会])
(pISSN: 0022-0345, eISSN: 1544-0591)

ISSN (任意): 1544-0591
ISSN: 0022-0345 (pISSN: 0022-0345, eISSN: 1544-0591)
Title: Journal of dental research
Title(ISO): J Dent Res
Publisher: SAGE Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2013年 5月 21日 (平成 25年 5月 21日) [継承]
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DOI (任意): 10.1177/0022034513491575    (→Scopusで検索) [継承]
PMID (任意): 23694929    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Orthodontics and Dentofacial Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8504, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Naoko Yoneda, Akihiro Yasue, Teppei Watanabe and Eiji Tanaka : Down-regulation of Smad3 Accelerates Palatal Wound Repair., Journal of Dental Research, Vol.92, No.8, 716-720, 2013.
欧文冊子 ● Naoko Yoneda, Akihiro Yasue, Teppei Watanabe and Eiji Tanaka : Down-regulation of Smad3 Accelerates Palatal Wound Repair., Journal of Dental Research, Vol.92, No.8, 716-720, 2013.

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