『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=265130EID:265130, Map:0, LastModified:2013年7月25日(木) 08:43:58, Operator:[高浜 洋介], Avail:TRUE, Censor:0, Owner:[高浜 洋介], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Lkhagvasuren Enkhsaikhan (日) (読)
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学籍番号 (推奨):
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2. (英) Sakata Mie (日) (読)
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3.大東 いずみ ([徳島大学.先端酵素学研究所.重点研究部門])
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4.高浜 洋介
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題名 (必須): (英) Lymphotoxin receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Medullary thymic epithelial cells (mTECs) play a pivotal role in the establishment of self-tolerance in T cells by ectopically expressing various tissue-restricted self-Ags and by chemoattracting developing thymocytes. The nuclear protein Aire expressed by mTECs contributes to the promiscuous expression of self-Ags, whereas CCR7-ligand (CCR7L) chemokines expressed by mTECs are responsible for the attraction of positively selected thymocytes. It is known that lymphotoxin signals from the positively selected thymocytes preferentially promote the expression of CCR7L rather than Aire in postnatal mTECs. However, it is unknown how lymphotoxin signals differentially regulate the expression of CCR7L and Aire in mTECs and whether CCR7L-expressing mTECs and Aire-expressing mTECs are distinct populations. In this study, we show that the majority of postnatal mTECs that express CCL21, a CCR7L chemokine, represent an mTEC subpopulation distinct from the Aire-expressing mTEC subpopulation. Interestingly, the development of CCL21-expressing mTECs, but not Aire-expressing mTECs, is impaired in mice deficient in the lymphotoxin receptor. These results indicate that postnatal mTECs consist of heterogeneous subsets that differ in the expression of CCL21 and Aire, and that lymphotoxin receptor regulates the development of the CCL21-expressing subset rather than the Aire-expressing subset of postnatal mTECs.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cell Differentiation (日) (読) [継承]
3. (英) Chemokine CCL21 (日) (読) [継承]
4. (英) Epithelial Cells (日) (読) [継承]
5. (英) Lymphotoxin beta Receptor (日) (読) [継承]
6. (英) Mice (日) (読) [継承]
7. (英) Mice, Inbred C57BL (日) (読) [継承]
8. (英) Mice, Knockout (日) (読) [継承]
9. (英) Receptors, CCR7 (日) (読) [継承]
10. (英) Signal Transduction (日) (読) [継承]
11. (英) Thymus Gland (日) (読) [継承]
12. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 190 [継承]
(必須): 10 [継承]
(必須): 5110 5117 [継承]
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年月日 (必須): 西暦 2013年 4月 12日 (平成 25年 4月 12日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.1203203    (→Scopusで検索) [継承]
PMID (任意): 23585674    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Enkhsaikhan Lkhagvasuren, Mie Sakata, Izumi Ohigashi and Yousuke Takahama : Lymphotoxin receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells., The Journal of Immunology, Vol.190, No.10, 5110-5117, 2013.
欧文冊子 ● Enkhsaikhan Lkhagvasuren, Mie Sakata, Izumi Ohigashi and Yousuke Takahama : Lymphotoxin receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells., The Journal of Immunology, Vol.190, No.10, 5110-5117, 2013.

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