『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=264872EID:264872, Map:0, LastModified:2018年11月28日(水) 16:48:40, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[松本 満], Read:継承, Write:継承, Delete:継承.
種別 (必須): 総説·解説 [継承]
言語 (必須): 英語 [継承]
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組織 (推奨): 1.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[次世代酵素学研究領域]) [継承]
著者 (必須): 1.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
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2.西川 裕美子
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3.西嶋 仁
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4.森本 純子 ([徳島大学.先端酵素学研究所.重点研究部門])
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5. (英) Matsumoto Minoru (日) (読)
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6.毛利 安宏 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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題名 (必須): (英) Which model better fits the role of Aire in the establishment of self-tolerance: the transcription model or the maturation model?  (日)    [継承]
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要約 (任意): (英) The discovery of Aire-dependent transcriptional control of many tissue-restricted self-antigen (TRA) genes in thymic epithelial cells in the medulla (medullary thymic epithelial cells, mTECs) has raised the intriguing question of how the single Aire gene can influence the transcription of such a large number of TRA genes within mTECs. From a mechanistic viewpoint, there are two possible models to explain the function of Aire in this action. In the first model, TRAs are considered to be the direct target genes of Aire's transcriptional activity. In this scenario, the lack of Aire protein within cells would result in the defective TRA gene expression, while the maturation program of mTECs would be unaffected in principle. The second model hypothesizes that Aire is necessary for the maturation program of mTECs. In this case, we assume that the mTEC compartment does not mature normally in the absence of Aire. If acquisition of the properties of TRA gene expression depends on the maturation status of mTECs, a defect of such an Aire-dependent maturation program in Aire-deficient mTECs can also result in impaired TRA gene expression. In this brief review, we will focus on these two contrasting models for the roles of Aire in controlling the expression of TRAs within mTECs.  (日)    [継承]
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誌名 (必須): Frontiers in Immunology (Frontiers Research Foundation)
(eISSN: 1664-3224)

ISSN (任意): 1664-3224
ISSN: 1664-3224 (eISSN: 1664-3224)
Title: Frontiers in immunology
Title(ISO): Front Immunol
Publisher: Frontiers Media S.A.
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年月日 (必須): 西暦 2013年 7月 22日 (平成 25年 7月 22日) [継承]
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DOI (任意): 10.3389/fimmu.2013.00210    (→Scopusで検索) [継承]
PMID (任意): 23885257    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-84883679216 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.3389/fimmu.2013.00210  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: autoimmunity  (日)    [継承]
4.(英) KeywordList.Keyword: cell differentiation  (日)    [継承]
5.(英) KeywordList.Keyword: gene transcription  (日)    [継承]
6.(英) KeywordList.Keyword: self-antigen  (日)    [継承]
7.(英) KeywordList.Keyword: thymic epithelial cell  (日)    [継承]

標準的な表示

和文冊子 ● Mitsuru Matsumoto, Yumiko Nishikawa, Hitoshi Nishijima, Junko Morimoto, Minoru Matsumoto and Yasuhiro Mouri : Which model better fits the role of Aire in the establishment of self-tolerance: the transcription model or the maturation model?, Frontiers in Immunology, Vol.4, (号), 1-4, July 2013.
欧文冊子 ● Mitsuru Matsumoto, Yumiko Nishikawa, Hitoshi Nishijima, Junko Morimoto, Minoru Matsumoto and Yasuhiro Mouri : Which model better fits the role of Aire in the establishment of self-tolerance: the transcription model or the maturation model?, Frontiers in Immunology, Vol.4, (号), 1-4, July 2013.

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