『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=264738EID:264738, Map:0, LastModified:2013年7月19日(金) 18:25:26, Operator:[細川 義隆], Avail:TRUE, Censor:0, Owner:[細川 義隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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著者 (必須): 1.細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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2.細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学])
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3. (英) Shindo Satoru (日) (読)
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4.尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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5.松尾 敬志
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題名 (必須): (英) (-)-Epigallocatechin-3-Gallate Inhibits CC Chemokine Ligand 11 Production in Human Gingival Fibroblasts.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Background: CC chemokine ligand 11 (CCL11) is related to Th2 cells migration via CC chemokine receptor 3 (CCR3). Th2 cells are involved in the etiology of periodontal disease. However, how the infiltration of Th2 cells is controlled in periodontally diseased tissues is unknown. (-)-Epigallocatechin gallate (EGCG), the major catechin in green tea, has multiple beneficial effects, but the effects of EGCG on CCL11 production are uncertain. In this study, we investigated whether cytokines could induce CCL11 production in human gingival fibroblasts (HGFs). Moreover, we examined the effects of EGCG on CCL11 production in HGFs. Methods and Results: ELISA analysis disclosed that interleukin (IL)-4 synergistically enhanced CCL11 production in IL-1 or tumor necrosis factor (TNF)--stimulated HGFs. EGCG prevented IL-1/ IL-4 or TNF-/IL-4-mediated CCL11 production in a concentration dependent manner. CCL11 production in HGFs was positively regulated by p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK), and c-Jun N terminal kinase (JNK). Western blot analysis revealed that EGCG treatment prevented IL-1/IL-4 or TNF-/IL-4-induced ERK and JNK activation in HGFs. Conclusions: These data provide that CCL11 production in HGFs could be associated with Th2 cells infiltration in periodontal lesions. Moreover, EGCG is useful for periodontitis treatment to inhibit CCL11 production.  (日)    [継承]
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誌名 (必須): Cellular Physiology and Biochemistry (S. Karger AG, Basel)
(pISSN: 1015-8987, eISSN: 1421-9778)

ISSN (任意): 1421-9778
ISSN: 1015-8987 (pISSN: 1015-8987, eISSN: 1421-9778)
Title: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Title(ISO): Cell Physiol Biochem
Publisher: Cell Physiol Biochem Press
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(必須): 960 967 [継承]
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年月日 (必須): 西暦 2013年 6月 26日 (平成 25年 6月 26日) [継承]
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DOI (任意): 10.1159/000350114    (→Scopusで検索) [継承]
PMID (任意): 23839108    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Conservative Dentistry and Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo : (-)-Epigallocatechin-3-Gallate Inhibits CC Chemokine Ligand 11 Production in Human Gingival Fibroblasts., Cellular Physiology and Biochemistry, Vol.31, No.6, 960-967, 2013.
欧文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo : (-)-Epigallocatechin-3-Gallate Inhibits CC Chemokine Ligand 11 Production in Human Gingival Fibroblasts., Cellular Physiology and Biochemistry, Vol.31, No.6, 960-967, 2013.

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