『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=264736EID:264736, Map:0, LastModified:2013年7月19日(金) 18:24:12, Operator:[細川 義隆], Avail:TRUE, Censor:0, Owner:[細川 義隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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著者 (必須): 1.細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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2.細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学])
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3. (英) Shindo Satoru (日) (読)
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4.尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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5.松尾 敬志
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題名 (必須): (英) TLR3 agonist enhances CC chemokine ligand 20 production in IL-1-stimulated human gingival fibroblasts.  (日)    [継承]
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要約 (任意): (英) Viruses are related to the etiology of periodontitis. However, the role of viruses on Th17 cells infiltration in periodontitis lesions is unknown. Therefore, we examined the effects of TLR3 ligand on CCL20, which is related to Th17 cells migration, production in human gingival fibroblasts (HGFs). Polyinosinic-polycytidylic acid (Poly I:C), which is a TLR3 agonist, stimulation could moderately induce CCL20 production in HGFs. Poly I:C synergistically enhanced CCL20 expression from IL-1-stimulated HGFs. Inhibitors of p38 MAPK, extracellular signal-regulated kinase (ERK), c-Jun N terminal kinase (JNK), and NF-B significantly inhibited CCL20 production in Poly I:C/IL-1-stimulated HGFs. Western blot analysis disclosed phosphorylation of p38 MAPK, JNK, and IB- were enhanced in Poly I:C/IL-1-treated HGFs. These data suggested that virus infection is related to Th17 cells migration in periodontitis lesion to induce CCL20 production in HGFs via TLR3. Therefore, our results indicated that virus might be important pathogen in periodontal disease.  (日)    [継承]
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誌名 (必須): Cellular Immunology ([Elsevier])
(pISSN: 0008-8749, eISSN: 1090-2163)

ISSN (任意): 1090-2163
ISSN: 0008-8749 (pISSN: 0008-8749, eISSN: 1090-2163)
Title: Cellular immunology
Title(ISO): Cell Immunol
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2013年 5月 31日 (平成 25年 5月 31日) [継承]
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DOI (任意): 10.1016/j.cellimm.2013.05.005    (→Scopusで検索) [継承]
PMID (任意): 23850670    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. Electronic address: hosokawa@tokushima-u.ac.jp.  (日)    [継承]
2.(英) PublicationType: JOURNAL ARTICLE  (日)    [継承]

標準的な表示

和文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo : TLR3 agonist enhances CC chemokine ligand 20 production in IL-1-stimulated human gingival fibroblasts., Cellular Immunology, Vol.283, No.1-2, 8-11, 2013.
欧文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki and Takashi Matsuo : TLR3 agonist enhances CC chemokine ligand 20 production in IL-1-stimulated human gingival fibroblasts., Cellular Immunology, Vol.283, No.1-2, 8-11, 2013.

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