『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[次世代酵素学研究領域]) [継承]
著者 (必須): 1.西川 裕美子
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.廣田 史子
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.矢野 雅司 ([徳島大学.技術支援部])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Hiroyuki Kitajima (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Jun-ichi Miyazaki (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Hiroshi Kawamoto (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7.毛利 安宏 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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学籍番号 (推奨):
[継承]
8.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation  (日)    [継承]
副題 (任意):
要約 (任意): (英) The roles of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) in the organization of the thymic microenvironment for establishing self-tolerance are enigmatic. We sought to monitor the production and maintenance of Aire-expressing mTECs by a fate-mapping strategy in which bacterial artificial chromosome transgenic (Tg) mice expressing Cre recombinase under the control of the Aire regulatory element were crossed with a GFP reporter strain. We found that, in addition to its well recognized expression within mature mTECs, Aire was expressed in the early embryo before emergence of the three germ cell layers. This observation may help to explain the development of ectodermal dystrophy often seen in patients with AIRE deficiency. With the use of one Tg line in which Cre recombinase expression was confined to mTECs, we found that Aire(+)CD80(high) mTECs further progressed to an Aire(-)CD80(intermediate) stage, suggesting that Aire expression is not constitutive from after its induction until cell death but instead is down-regulated at the beginning of terminal differentiation. We also demonstrated that many mTECs of Aire-expressing lineage are in close contact with thymic dendritic cells. This close proximity may contribute to transfer of tissue-restricted self-antigens expressed by mTECs to professional antigen-presenting cells.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cell Differentiation (日) (読) [継承]
3. (英) Embryonic Development (日) (読) [継承]
4. (英) Epithelial Cells (日) (読) [継承]
5. (英) Gene Expression Regulation (日) (読) [継承]
6. (英) Genes, Reporter (日) (読) [継承]
7. (英) Green Fluorescent Proteins (日) (読) [継承]
8. (英) Lymphoid Tissue (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Mice, Transgenic (日) (読) [継承]
12. (英) Spermatogenesis (日) (読) [継承]
13. (英) Testis (日) (読) [継承]
14. (英) Thymus Gland (日) (読) [継承]
15. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨): The Rockefeller University Press [継承]
誌名 (必須): The Journal of Experimental Medicine ([The Rockefeller University Press])
(pISSN: 0022-1007, eISSN: 1540-9538)

ISSN (任意): 1540-9538
ISSN: 0022-1007 (pISSN: 0022-1007, eISSN: 1540-9538)
Title: The Journal of experimental medicine
Title(ISO): J Exp Med
Publisher: Rockefeller University Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 207 [継承]
(必須): 5 [継承]
(必須): 963 971 [継承]
都市 (任意):
年月日 (必須): 西暦 2010年 5月 10日 (平成 22年 5月 10日) [継承]
URL (任意):
DOI (任意): 10.1084/jem.20092144    (→Scopusで検索) [継承]
PMID (任意): 20404099    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC2867289  (日)    [継承]

標準的な表示

和文冊子 ● Yumiko Nishikawa, Fumiko Hirota, Masashi Yano, Kitajima Hiroyuki, Miyazaki Jun-ichi, Kawamoto Hiroshi, Yasuhiro Mouri and Mitsuru Matsumoto : Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation, The Journal of Experimental Medicine, Vol.207, No.5, 963-971, 2010.
欧文冊子 ● Yumiko Nishikawa, Fumiko Hirota, Masashi Yano, Kitajima Hiroyuki, Miyazaki Jun-ichi, Kawamoto Hiroshi, Yasuhiro Mouri and Mitsuru Matsumoto : Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation, The Journal of Experimental Medicine, Vol.207, No.5, 963-971, 2010.

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