『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=264552)

EID=264552EID:264552, Map:0, LastModified:2018年2月13日(火) 11:43:20, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院医歯薬学研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.林 幸壱朗
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.中村 教泰
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.石村 和敬
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Near-Infrared Fluorescent Silica-Coated Gold Nanoparticle Clusters for X-Ray Computed Tomography/Optical Dual Modal Imaging of the Lymphatic System  (日)    [継承]
副題 (任意):
要約 (任意): (英) Lymph nodes (LNs) are often removed to prevent the spread of cancer because they are frequently the first site of metastases. However, the enucleation of LNs requires difficult operative techniques and lymphedema can result as a complication. Although lymphedema can be cured by anastomosis of a lymph vessel (LV) to a vein, the operative procedure is extremely difficult because LNs and LVs are too small and indistinct to be identified. Therefore, visualization of LNs and LVs is important. The combination of X-ray computed tomography (CT) and fluorescence imaging, CT/fluorescence dual modal imaging, enables the visualization of LNs and LVs before and during surgery. To accomplish this, near-infrared fluorescent silica-coated gold nanoparticle clusters (Au@SiO2) with a high X-ray absorption coefficient are synthesized. Both fluorescence imaging and CT show that the Au@SiO2 nanoparticles gradually accumulate in LNs through LVs. CT determines the location and size of the LNs and LVs without dissection, and fluorescence imaging facilitates their identification. The Au@SiO2 nanoparticles have neither hepatotoxicity nor nephrotoxicity. The results demonstrate that CT/fluorescence dual modal imaging using Au@SiO2 nanoparticles provides anatomical information, including the location and size of LNs and LVs for determining a surgery plan, and provides intraoperative visualization of LNs and LVs to facilitate the operation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Contrast Media (日) (読) [継承]
3. (英) Fluorescent Dyes (日) (読) [継承]
4. (英) Gold (日) (読) [継承]
5. (英) Lymphatic System (日) (読) [継承]
6. (英) Lymphography (日) (読) [継承]
7. (英) Metal Nanoparticles (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Mice, Inbred C57BL (日) (読) [継承]
10. (英) Microscopy, Fluorescence (日) (読) [継承]
11. (英) Subtraction Technique (日) (読) [継承]
12. (英) Tomography, X-Ray Computed (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Advanced Healthcare Materials ([John Wiley & Sons, Inc.])
(pISSN: 2192-2640, eISSN: 2192-2659)

ISSN (任意): 2192-2640
ISSN: 2192-2640 (pISSN: 2192-2640, eISSN: 2192-2659)
Title: Advanced healthcare materials
Title(ISO): Adv Healthc Mater
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 2 [継承]
(必須): 5 [継承]
(必須): 756 763 [継承]
都市 (任意):
年月日 (必須): 西暦 2013年 5月 初日 (平成 25年 5月 初日) [継承]
URL (任意):
DOI (任意): 10.1002/adhm.201200238    (→Scopusで検索) [継承]
PMID (任意): 23184510    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000318312200015 [継承]
Scopus (任意): 2-s2.0-84879608269 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.1002/adhm.201200238  (日)    [継承]
2.(英) Article.Affiliation: Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Japan. khayashi@basic.med.tokushima-u.ac.jp  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Koichiro Hayashi, Michihiro Nakamura and Kazunori Ishimura : Near-Infrared Fluorescent Silica-Coated Gold Nanoparticle Clusters for X-Ray Computed Tomography/Optical Dual Modal Imaging of the Lymphatic System, Advanced Healthcare Materials, Vol.2, No.5, 756-763, 2013.
欧文冊子 ● Koichiro Hayashi, Michihiro Nakamura and Kazunori Ishimura : Near-Infrared Fluorescent Silica-Coated Gold Nanoparticle Clusters for X-Ray Computed Tomography/Optical Dual Modal Imaging of the Lymphatic System, Advanced Healthcare Materials, Vol.2, No.5, 756-763, 2013.

関連情報

Number of session users = 3, LA = 1.01, Max(EID) = 372499, Max(EOID) = 996243.