『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=264550EID:264550, Map:0, LastModified:2018年2月13日(火) 16:03:22, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[三木 浩和], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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著者 (必須): 1.林 幸壱朗
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2.中村 教泰
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3. (英) Sakamoto Wataru (日) 坂本 渉 (読) さかもと わたる
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4. (英) Yogo Toshinobu (日) 余語 利信 (読) よご としのぶ
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5.三木 浩和 ([徳島大学.病院.中央診療施設等.輸血・細胞治療部])
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6.尾崎 修治
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7.安倍 正博 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.血液・内分泌代謝内科学])
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8.松本 俊夫
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9.石村 和敬
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題名 (必須): (英) "Superparamagnetic Nanoparticle Clusters for Cancer Theranostics Combining Magnetic Resonance Imaging and Hyperthermia Treatment  (日)    [継承]
副題 (任意):
要約 (任意): (英) Superparamagnetic nanoparticles (SPIONs) could enable cancer theranostics if magnetic resonance imaging (MRI) and magnetic hyperthermia treatment (MHT) were combined. However, the particle size of SPIONs is smaller than the pores of fenestrated capillaries in normal tissues because superparamagnetism is expressed only at a particle size <10 nm. Therefore, SPIONs leak from the capillaries of normal tissues, resulting in low accumulation in tumors. Furthermore, MHT studies have been conducted in an impractical way: direct injection of magnetic materials into tumor and application of hazardous alternating current (AC) magnetic fields. To accomplish effective enhancement of MRI contrast agents in tumors and inhibition of tumor growth by MHT with intravenous injection and a safe AC magnetic field, we clustered SPIONs not only to prevent their leakage from fenestrated capillaries in normal tissues, but also for increasing their relaxivity and the specific absorption rate. We modified the clusters with folic acid (FA) and polyethylene glycol (PEG) to promote their accumulation in tumors. SPION clustering and cluster modification with FA and PEG were achieved simultaneously via the thiol-ene click reaction. Twenty-four hours after intravenous injection of FA- and PEG-modified SPION nanoclusters (FA-PEG-SPION NCs), they accumulated locally in cancer (not necrotic) tissues within the tumor and enhanced the MRI contrast. Furthermore, 24 h after intravenous injection of the NCs, the mice were placed in an AC magnetic field with H = 8 kA/m and f = 230 kHz (Hf = 1.8×10(9) A/m∙s) for 20 min. The tumors of the mice underwent local heating by application of an AC magnetic field. The temperature of the tumor was higher than the surrounding tissues by ≈6°C at 20 min after treatment. Thirty-five days after treatment, the tumor volume of treated mice was one-tenth that of the control mice. Furthermore, the treated mice were alive after 12 weeks; control mice died up to 8 weeks after treatment.  (日)    [継承]
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誌名 (必須): Theranostics (Ivyspring International Publisher)
(eISSN: 1838-7640)

ISSN (任意): 1838-7640
ISSN: 1838-7640 (eISSN: 1838-7640)
Title: Theranostics
Title(ISO): Theranostics
Publisher: Ivyspring International Publisher
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 3 [継承]
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(必須): 366 376 [継承]
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年月日 (必須): 西暦 2013年 4月 23日 (平成 25年 4月 23日) [継承]
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DOI (任意): 10.7150/thno.5860    (→Scopusで検索) [継承]
PMID (任意): 23781284    (→Scopusで検索) [継承]
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WOS (任意): 000321058100002 [継承]
Scopus (任意): 2-s2.0-84882252518 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.7150/thno.5860  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC3677408  (日)    [継承]
5.(英) KeywordList.Keyword: MRI  (日)    [継承]
6.(英) KeywordList.Keyword: hyperthermia  (日)    [継承]
7.(英) KeywordList.Keyword: iron oxide  (日)    [継承]
8.(英) KeywordList.Keyword: nanomedicine  (日)    [継承]
9.(英) KeywordList.Keyword: theranostics  (日)    [継承]
10.(英) KeywordList.Keyword: tumor.  (日)    [継承]

標準的な表示

和文冊子 ● Koichiro Hayashi, Michihiro Nakamura, Wataru Sakamoto, Toshinobu Yogo, Hirokazu Miki, Shuji Ozaki, Masahiro Abe, Toshio Matsumoto and Kazunori Ishimura : "Superparamagnetic Nanoparticle Clusters for Cancer Theranostics Combining Magnetic Resonance Imaging and Hyperthermia Treatment, Theranostics, Vol.3, No.6, 366-376, 2013.
欧文冊子 ● Koichiro Hayashi, Michihiro Nakamura, Wataru Sakamoto, Toshinobu Yogo, Hirokazu Miki, Shuji Ozaki, Masahiro Abe, Toshio Matsumoto and Kazunori Ishimura : "Superparamagnetic Nanoparticle Clusters for Cancer Theranostics Combining Magnetic Resonance Imaging and Hyperthermia Treatment, Theranostics, Vol.3, No.6, 366-376, 2013.

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