| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 廣島 佑香 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔微生物学])
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| 2. | 板東 美香 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学]/[徳島大学.病院.診療科.歯科.歯周病科(第二保存科)])
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| 3. | 稲垣 裕司 ([徳島大学.病院.診療科.歯科.歯周病科(第二保存科)])
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| 4. | 美原(和田) 智恵 ([徳島大学.病院.中央診療施設等.総合歯科診療部])
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| 5. | 片岡 正俊
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| 6. | 村田 裕美 ([徳島大学.病院.診療科.歯科.歯周病科(第二保存科)])
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| 7. | 篠原 康雄 ([徳島大学.先端酵素学研究所.基幹研究部門])
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| 8. | 永田 俊彦
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| 9. | 木戸 淳一
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| ○題名 (必須): | □ | (英) Resistin in gingival crevicular fluid and induction of resistin release by Porphyromonas gingivalis lipopolysaccharide in human neutrophils (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Resistin is an adipocytokine that induces insulin resistance and is predominantly expressed in adipocytes and peripheral blood mononuclear cells. Resistin expression increases in inflammatory diseases as well as diabetes mellitus, and is upregulated by bacterial pathogens and proinflammatory cytokines. The aim of this study was to identify resistin in human gingival crevicular fluid, to compare the resistin levels in gingival crevicular fluid between subjects with and without periodontitis and diabetes mellitus and to investigate the regulation of resistin release from human neutrophils by Porphyromonas gingivalis lipopolysaccharide (P-LPS). Gingival crevicular fluid samples were collected from patients with chronic periodontitis (n = 24), patients with diabetes mellitus-related periodontitis (n = 18) and healthy subjects (n = 21). Resistin in gingival crevicular fluid was determined using western blot analysis and an ELISA kit. The glycated hemoglobin (HbA(1c)) value was obtained from patients with diabetes mellitus-related periodontitis by a medical interview. Human neutrophils were cultured with P-LPS (0-1000 ng/mL), or incubated with inhibitors of actin or microtubule polymerization in the absence or presence of P-LPS. The medium and cellular fractions were used for determination of resistin by ELISA. The resistin level in gingival crevicular fluid from patients with periodontitis or diabetes mellitus-related periodontitis was significantly higher than that of healthy subjects. The resistin level in gingival crevicular fluid was correlated with gingival index score, but not blood HbA(1c) value. The P-LPS increased resistin release from human neutrophils, and its induction was decreased by actin polymerization inhibitors. We show, for the first time, the presence of resistin in gingival crevicular fluid. A high resistin level in gingival crevicular fluid samples from periodontitis patients may to some extent be related to P-LPS-induced resistin release from neutrophils. (日)
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| ○キーワード (推奨): | 1. | (英) Actin Capping Proteins (日) (読)
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| 2. | (英) Adult (日) (読)
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| 3. | (英) Aged (日) (読)
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| 4. | (英) Cell Culture Techniques (日) (読)
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| 5. | (英) Chronic Periodontitis (日) (読)
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| 6. | (英) Colchicine (日) (読)
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| 7. | (英) Cytochalasin B (日) (読)
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| 8. | (英) Cytochalasin D (日) (読)
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| 9. | (英) Diabetes Complications (日) (読)
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| 10. | (英) Female (日) (読)
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| 11. | (英) Gingival Crevicular Fluid (日) (読)
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| 12. | (英) Hemoglobin A, Glycosylated (日) (読)
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| 13. | (英) Humans (日) (読)
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| 14. | (英) Lipopolysaccharides (日) (読)
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| 15. | (英) Male (日) (読)
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| 16. | (英) Middle Aged (日) (読)
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| 17. | (英) Neutrophils (日) (読)
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| 18. | (英) Nocodazole (日) (読)
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| 19. | (英) Nucleic Acid Synthesis Inhibitors (日) (読)
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| 20. | (英) Periodontal Index (日) (読)
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| 21. | (英) Periodontal Pocket (日) (読)
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| 22. | (英) Periodontitis (日) (読)
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| 23. | (英) Porphyromonas gingivalis (日) (読)
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| 24. | (英) Resistin (日) (読)
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| 25. | (英) Tubulin Modulators (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Periodontal Research ([Blackwell Publishing Ltd])
(pISSN: 0022-3484, eISSN: 1600-0765)
| ○ISSN (任意): | □ | 1600-0765
ISSN: 0022-3484
(pISSN: 0022-3484, eISSN: 1600-0765) Title: Journal of periodontal researchTitle(ISO): J Periodontal ResPublisher: Blackwell (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 47
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 554 562
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2012年 2月 6日 (平成 24年 2月 6日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/j.1600-0765.2011.01466.x (→Scopusで検索)
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| ○PMID (任意): | □ | 22309231 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000307974000002
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| ○Scopus (任意): | □ | 2-s2.0-84865553635
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| ○評価値 (任意): |
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1111/j.1600-0765.2011.01466.x (日)
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| 2. | (英) Article.Affiliation: Department of Periodontology and Endodontology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Comparative Study (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 5. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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