『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=263658EID:263658, Map:0, LastModified:2014年1月27日(月) 14:12:47, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.大学院ソシオテクノサイエンス研究部.ライフシステム部門 (2006年4月1日〜) [継承]
著者 (必須): 1. (英) Hirota Keiji (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Nakagawa Yoshinori (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Takeuchi Ryota (日) (読)
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[継承]
4.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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学籍番号 (推奨):
[継承]
5.堀 均
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学籍番号 (推奨):
[継承]
6. (英) Onizuka Shinya (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7.寺田 弘 ([東京理科大学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Antitumor Effect of Degalactosylated Gc-Globulin on Orthotopic Grafted Lung Cancer in Mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) Group-specific component (Gc)-globulin-derived macrophage-activating factor (GcMAF) generated by a cascade of catalytic reactions with deglycosidase enzymes exerts antitumor activity. We hypothesized that degalactosyl Gc-globulin (DG3), a precursor of GcMAF, also plays a role in recovery from cancer as well as GcMAF due to progression of deglycosylation by generally resident sialidases and mannosidases. We prepared the subtypes of DG3, such as 1f1f and 1s1s and its 22 homodimers, by using vitamin D3-binding Sepharose CL-6B and examined their antitumor activity in mice bearing Lewis lung carcinoma cells, by counting the number of nodules formed in their lungs. Antitumor activity of DG3 was observed regardless of its subtype, being equivalent to that of GcMAF. The injection route of DG3 affected its antitumor activity, with subcutaneous and intramuscular administration being more favorable than the intraperitoneal or intravenous route. In order to obtain significant antitumor activity, more than 160 ng/kg of DG3 were required. DG3 proved to be promising as an antitumor agent, similarly to GcMAF.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Carcinoma, Lewis Lung (日) (読) [継承]
3. (英) Female (日) (読) [継承]
4. (英) Galactose (日) (読) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) Injections, Intramuscular (日) (読) [継承]
7. (英) Injections, Intraperitoneal (日) (読) [継承]
8. (英) Injections, Intravenous (日) (読) [継承]
9. (英) Injections, Subcutaneous (日) (読) [継承]
10. (英) Macrophage-Activating Factors (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Mice, Inbred C57BL (日) (読) [継承]
13. (英) Vitamin D-Binding Protein (日) (読) [継承]
発行所 (推奨): (英) The International Institute of Anticancer Research (日) (読) [継承]
誌名 (必須): Anticancer Research (International Institute of Anticancer Research(IIAR))
(pISSN: 0250-7005, eISSN: 1791-7530)

ISSN (任意): 1791-7530
ISSN: 0250-7005 (pISSN: 0250-7005, eISSN: 1791-7530)
Title: Anticancer research
Title(ISO): Anticancer Res.
Publisher: International Institute of Anticancer Research
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 33 [継承]
(必須): 7 [継承]
(必須): 2911 2915 [継承]
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年月日 (必須): 西暦 2013年 6月 末日 (平成 25年 6月 末日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 23780979    (→Scopusで検索) [継承]
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WOS (任意): 000320833300016 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, 2-1 Minamijosanjimacho, Tokushima 770-8506, Japan. uto@bio.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Keiji Hirota, Yoshinori Nakagawa, Ryota Takeuchi, Yoshihiro Uto, Hitoshi Hori, Shinya Onizuka and Hiroshi Terada : Antitumor Effect of Degalactosylated Gc-Globulin on Orthotopic Grafted Lung Cancer in Mice, Anticancer Research, Vol.33, No.7, 2911-2915, 2013.
欧文冊子 ● Keiji Hirota, Yoshinori Nakagawa, Ryota Takeuchi, Yoshihiro Uto, Hitoshi Hori, Shinya Onizuka and Hiroshi Terada : Antitumor Effect of Degalactosylated Gc-Globulin on Orthotopic Grafted Lung Cancer in Mice, Anticancer Research, Vol.33, No.7, 2911-2915, 2013.

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