『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨):
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1. (英) Fukudome, K. (日) (読)
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
2. (英) Furuse, M (日) (読)
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○学籍番号 (推奨):
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3. (英) Fukuhara, N. (日) (読)
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○学籍番号 (推奨):
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4.織田 聡
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○学籍番号 (推奨):
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5. (英) Imai, T. (日) (読)
○役割 (任意):
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○学籍番号 (推奨):
[継承]
○題名 (必須): □(英) Strong induction of ICAM-1 in human T cells transformed by human T-cell-leukemia virus type 1 and depression of ICAM-1 or LFA-1 in adult T-cell-leukemia-derived cell lines.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) Sixteen human T-cell lines were studied for the expression of a cell-adhesion molecule ICAM-1 and its counter-receptor LFA-1. The cell lines included 3 human T-cell-leukemia-virus-type-I (HTLV-1)-negative cell lines derived from acute lymphoblastic leukemia (ALL) and 13 HTLV-1-positive cell lines, 7 of them established from cord- or peripheral-blood T cells by in vitro transformation with HTLV-1, 2 derived from HTLV-1 carriers, and 4 derived from patients with adult T-cell leukemia (ATL). In sharp contrast to a basal level of ICAM-1 in 3 HTLV-1-negative ALL cell lines, strong induction of ICAM-1 was seen in all HTLV-1-positive T-cell lines except for MT-1, one of the 4 ATL cell lines used in the present study. On the other hand, the expression of LFA-1 (CD11a and CD18) was more or less similar among the cell lines with and without HTLV-1. Interestingly, however, 3 out of 4 ATL cell lines (TL-Om1, H582, HUT102) revealed striking depression of LFA-1 expression. Several lines of evidence strongly argued against direct involvement of the viral transactivator p40tax or some autocrine cytokines in the induction of ICAM-1 in HTLV-1-positive T-cell lines. It was also found that ICAM-1 and LFA-1 were involved in syncytium formation induced in the co-culture of HTLV-1-positive and HTLV-1-negative human T-cell lines. Implications of constitutive expression of ICAM-1 for certain clinical manifestations of ATL and of depression of either ICAM-1 or LFA-1 during progression of ATL are discussed.  (日)    [継承]
○キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antibodies, Monoclonal (日) (読) [継承]
3. (英) Base Sequence (日) (読) [継承]
4. (英) Blotting, Northern (日) (読) [継承]
5. (英) Cell Adhesion Molecules (日) (読) [継承]
6. (英) Cell Transformation, Viral (日) (読) [継承]
7.細胞質分裂 (cytokinesis) [継承]
8. (英) Flow Cytometry (日) (読) [継承]
9. (英) Gene Products, tax (日) (読) [継承]
10. (英) Human T-lymphotropic virus 1 (日) (読) [継承]
11. (英) Humans (日) (読) [継承]
12. (英) Intercellular Adhesion Molecule-1 (日) (読) [継承]
13. (英) Leukemia, T-Cell (日) (読) [継承]
14. (英) Lymphocyte Function-Associated Antigen-1 (日) (読) [継承]
15. (英) Mice (日) (読) [継承]
16. (英) Molecular Sequence Data (日) (読) [継承]
17. (英) RNA, Messenger (日) (読) [継承]
18.Tリンパ球 (T lymphocytes) [継承]
19. (英) Tumor Cells, Cultured (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □International Journal of Cancer ([国際対ガン連合])
(pISSN: 0020-7136, eISSN: 1097-0215)

○ISSN (任意): □0020-7136
ISSN: 0020-7136 (pISSN: 0020-7136, eISSN: 1097-0215)
Title: International journal of cancer
Title(ISO): Int J Cancer
Supplier: Union for International Cancer Control
Publisher: Wiley
 (NLM Catalog)   (Wiley)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □52 [継承]
○号 (必須): □3 [継承]
○頁 (必須): □418 427 [継承]
○都市 (任意):
○年月日 (必須): □西暦 1992年 9月 30日 (平成 4年 9月 30日) [継承]
○URL (任意):
○DOI (任意): □10.1002/ijc.2910520316    (→Scopusで検索) [継承]
○PMID (任意): □1356935    (→Scopusで検索) [継承]
○CRID (任意):
○WOS (任意):
○Scopus (任意): □2-s2.0-0026758209 [継承]
○評価値 (任意):
○被引用数 (任意):
○指導教員 (推奨):
○備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● K. Fukudome, M Furuse, N. Fukuhara, Satoshi Orita and T. Imai : Strong induction of ICAM-1 in human T cells transformed by human T-cell-leukemia virus type 1 and depression of ICAM-1 or LFA-1 in adult T-cell-leukemia-derived cell lines., International Journal of Cancer, Vol.52, No.3, 418-427, 1992.
欧文冊子 ● K. Fukudome, M Furuse, N. Fukuhara, Satoshi Orita and T. Imai : Strong induction of ICAM-1 in human T cells transformed by human T-cell-leukemia virus type 1 and depression of ICAM-1 or LFA-1 in adult T-cell-leukemia-derived cell lines., International Journal of Cancer, Vol.52, No.3, 418-427, 1992.

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