『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=262708EID:262708, Map:0, LastModified:2018年5月4日(金) 17:09:22, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[北岡 和義], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.北岡 和義 ([徳島大学.教養教育院])
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2. (英) Shimizu Noriyuki (日) 清水 紀之 (読) しみず のりゆき
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学籍番号 (推奨): **** [ユーザ]
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3.小野 公嗣
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4.近久 幸子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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5. (英) Nakagomi Madoka (日) (読)
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6. (英) Shudo Koichi (日) (読)
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7.石村 和敬
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8.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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9.吉﨑 和男
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題名 (必須): (英) The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice  (日)    [継承]
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要約 (任意): (英) The retinoic acid (RA, a vitamin A metabolite) receptor (RAR) is a transcription factor. Vitamin A/RA administration improves the Alzheimer's disease (AD)- and age-related attenuation of memory/learning in mouse models. Recently, a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) was identified as a key molecule in RA-mediated anti-AD mechanisms. We investigated the effect of chronic administration of the RAR agonist Am80 (tamibarotene) on ADAM10 expression in senescence-accelerated mice (SAMP8). Moreover, we estimated changes in the expression of the amyloid precursor protein (APP), amyloid beta (Aβ), and hairy/enhancer of split (Hes), which are mediated by ADAM10. Spatial working memory and the levels of a hippocampal proliferation marker (Ki67) were also assessed in these mice. ADAM10 mRNA and protein expression was significantly reduced in the hippocampus of 13-month-old SAMP8 mice; their expression improved significantly after Am80 administration. Further, after Am80 administration, the expression levels of Hes5 and Ki67 were restored and the deterioration of working memory was suppressed, whereas APP and Aβ levels remained unchanged. Our results suggest that Am80 administration effectively improves dementia by activating the hippocampal ADAM10-Notch-Hes5 proliferative pathway.  (日)    [継承]
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誌名 (必須): Neuropharmacology ([Pergamon Press])
(pISSN: 0028-3908, eISSN: 1873-7064)

ISSN (任意): 1873-7064
ISSN: 0028-3908 (pISSN: 0028-3908, eISSN: 1873-7064)
Title: Neuropharmacology
Title(ISO): Neuropharmacology
Publisher: Elsevier Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 58 65 [継承]
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年月日 (必須): 西暦 2013年 9月 初日 (平成 25年 9月 初日) [継承]
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DOI (任意): 10.1016/j.neuropharm.2013.04.009    (→Scopusで検索) [継承]
PMID (任意): 23624141    (→Scopusで検索) [継承]
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WOS (任意): 000321941800007 [継承]
Scopus (任意): 2-s2.0-84884865233 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.neuropharm.2013.04.009  (日)    [継承]
2.(英) Article.ELocationID: S0028-3908(13)00146-9  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kazuyoshi Kitaoka, Noriyuki Shimizu, Koji Ono, Sachiko Chikahisa, Madoka Nakagomi, Koichi Shudo, Kazunori Ishimura, Hiroyoshi Sei and Kazuo Yoshizaki : The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice, Neuropharmacology, Vol.72, (号), 58-65, 2013.
欧文冊子 ● Kazuyoshi Kitaoka, Noriyuki Shimizu, Koji Ono, Sachiko Chikahisa, Madoka Nakagomi, Koichi Shudo, Kazunori Ishimura, Hiroyoshi Sei and Kazuo Yoshizaki : The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice, Neuropharmacology, Vol.72, (号), 58-65, 2013.

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