『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
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共著種別 (推奨):
学究種別 (推奨): 博士課程学生による研究報告 [継承]
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.顎口腔再建医学講座.口腔顎顔面矯正学 (2004年4月1日〜2015年3月31日) [継承]
2.徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学 (2004年4月1日〜) [継承]
著者 (必須): 1.永田 久美子 ([徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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2.中村 竜也 ([徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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3.藤原 慎視
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4.田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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題名 (必須): (英) Ultrasound modulates the inflammatory response and promotes muscle regeneration in injured muscles.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The purpose of this study was to examine the effect of ultrasound on inflammatory skeletal muscle in vitro and in vivo. C2C12 cells were cultured in medium with or without TNF-α or IL-1β. After stimulation with cytokines, the cells received ultrasound or sham exposure. Furthermore, the tibialis anterior (TA) muscle in C57BL/6 mice injured by cardiotoxin (CTX) were dissected after a series of ultrasound treatments and examined. Exposure of C2C12 cells to ultrasound resulted in down-regulation of cyclooxygenase-2 (COX-2) mRNA and protein expression induced by TNF-α or IL-1β, and up-regulated myogenin mRNA and protein depressed by TNF-α or IL-1β. In injured TA muscle induced by CTX, ultrasound caused increase of COX-2 mRNA at 1 day after ultrasound treatment, however, at day 5, reduction of COX-2 mRNA and protein. At day 5, ultrasound caused increase of myogenin mRNA and protein, increase of fast myosin protein, and increase of paired-box transcription factor 7 positive cells. At day 7, the cross-sectional area of myofibers in the ultrasound exposure side was significantly larger than that on the control side. In conclusion, ultrasound stimulation may be a better candidate as a medical remedy to promote myogenesis in inflammatory muscle states, such as muscle injury.  (日) The purpose of this study was to examine the effect of ultrasound on inflammatory skeletal muscle in vitro and in vivo. C2C12 cells were cultured in medium with or without TNF-α or IL-1β. After stimulation with cytokines, the cells received ultrasound or sham exposure. Furthermore, the tibialis anterior (TA) muscle in C57BL/6 mice injured by cardiotoxin (CTX) were dissected after a series of ultrasound treatments and examined. Exposure of C2C12 cells to ultrasound resulted in down-regulation of cyclooxygenase-2 (COX-2) mRNA and protein expression induced by TNF-α or IL-1β, and up-regulated myogenin mRNA and protein depressed by TNF-α or IL-1β. In injured TA muscle induced by CTX, ultrasound caused increase of COX-2 mRNA at 1 day after ultrasound treatment, however, at day 5, reduction of COX-2 mRNA and protein. At day 5, ultrasound caused increase of myogenin mRNA and protein, increase of fast myosin protein, and increase of paired-box transcription factor 7 positive cells. At day 7, the cross-sectional area of myofibers in the ultrasound exposure side was significantly larger than that on the control side. In conclusion, ultrasound stimulation may be a better candidate as a medical remedy to promote myogenesis in inflammatory muscle states, such as muscle injury.   [継承]
キーワード (推奨): 1. (英) Acoustics (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Cell Line (日) (読) [継承]
4. (英) Cobra Venoms (日) (読) [継承]
5. (英) Cyclooxygenase 2 (日) (読) [継承]
6. (英) Gene Expression Regulation (日) (読) [継承]
7. (英) Interleukin-1beta (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Mice, Inbred C57BL (日) (読) [継承]
10. (英) Muscle, Skeletal (日) (読) [継承]
11. (英) Myogenin (日) (読) [継承]
12. (英) Myositis (日) (読) [継承]
13. (英) PAX7 Transcription Factor (日) (読) [継承]
14. (英) RNA, Messenger (日) (読) [継承]
15. (英) Regeneration (日) (読) [継承]
16. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Annals of Biomedical Engineering (Biomedical Engineering Society (BMES).)
(pISSN: 0090-6964, eISSN: 1573-9686)

ISSN (任意): 1573-9686
ISSN: 0090-6964 (pISSN: 0090-6964, eISSN: 1573-9686)
Title: Annals of biomedical engineering
Title(ISO): Ann Biomed Eng
Supplier: Kluwer Online
Publisher: Springer US
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 41 [継承]
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(必須): 1095 1105 [継承]
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年月日 (必須): 西暦 2013年 2月 6日 (平成 25年 2月 6日) [継承]
URL (任意):
DOI (任意): 10.1007/s10439-013-0757-y    (→Scopusで検索) [継承]
PMID (任意): 23386031    (→Scopusで検索) [継承]
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WOS (任意): 000318297000001 [継承]
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備考 (任意): 1.(英) Affiliation: Department of Orthodontics and Dentofacial Orthopedics, The University of Tokushima Graduate School of Oral Sciences, 3-18-15 Kuramoto-Cho, Tokushima, 770-8504, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kumiko Nagata, Tatsuya Nakamura, Shinji Fujihara and Eiji Tanaka : Ultrasound modulates the inflammatory response and promotes muscle regeneration in injured muscles., Annals of Biomedical Engineering, Vol.41, No.6, 1095-1105, 2013.
欧文冊子 ● Kumiko Nagata, Tatsuya Nakamura, Shinji Fujihara and Eiji Tanaka : Ultrasound modulates the inflammatory response and promotes muscle regeneration in injured muscles., Annals of Biomedical Engineering, Vol.41, No.6, 1095-1105, 2013.

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