| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): | □ | 研究生による研究報告
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| ○組織 (推奨): | 1. | 徳島大学.医学研究科.医学専攻 (2004年4月1日〜)
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| ○著者 (必須): | 1. | 多田 恵曜 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| 2. | (英) Kitazato T. Keiko (日) 北里 慶子 (読) キタザト ケイコ
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| 3. | 田村 哲也
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| 4. | 八木 謙次
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| 5. | 島田 健司 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.脳·神経·精神科.脳神経外科])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 6. | 木内 智也
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| 7. | 里見 淳一郎
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 8. | 永廣 信治
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| ○貢献度 (任意): |
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| 9. | 永廣 信治
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Role of mineralocorticoid receptor on experimental cerebral aneurysms in rats. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Activation of the renin-angiotensin (Ang)-aldosterone system is involved in the pathology of vascular diseases. Although the blockade of the mineralocorticoid receptor protects against vascular diseases, its role in cerebral aneurysms remains to be elucidated. We treated female rats subjected to renal hypertension, increased hemodynamic stress, and estrogen deficiency for 3 months with the mineralocorticoid receptor blocker eplerenone (30 or 100 mg/kg per day) or vehicle (vehicle control). Eplerenone reduced the incidence of cerebral aneurysms and saline intake without lowering of the blood pressure. In the aneurysmal wall, the production of Ang II and nitrotyrosine was increased. The mRNA levels of Ang-converting enzyme 1 and NADPH oxidase subunits NOX4, Rac1, monocyte chemoattractant protein 1, and matrix metalloproteinase 9 were increased. Eplerenone brought about a reduction in these molecules, suggesting that mineralocorticoid receptor blockade suppresses cerebral aneurysm formation by inhibiting oxidative stress, inflammatory factors, local renin-Ang system activation, and saline intake. Other female rats implanted with pellets of the mineralocorticoid receptor agonist deoxycorticosterone acetate manifested a high incidence of cerebral aneurysm formation and the upregulation of molecules related to oxidative stress, inflammatory factors, and the local renin-Ang system; their saline intake was increased. We demonstrate that mineralocorticoid receptor activation at least partly contributes to the pathogenesis of cerebral aneurysms. (日)
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| ○キーワード (推奨): | 1. | (英) Aldosterone (日) (読)
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| 2. | (英) Angiotensin II (日) (読)
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| 3. | (英) Animals (日) (読)
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| 4. | 血圧 (blood pressure)
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| 5. | (英) Cerebral Arteries (日) (読)
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| 6. | (英) Chemokine CCL2 (日) (読)
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| 7. | (英) Female (日) (読)
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| 8. | 遺伝子発現 (gene expression)
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| 9. | (英) Hypertension, Renal (日) (読)
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| 10. | 免疫組織化学 (immunohistochemistry)
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| 11. | (英) Intracranial Aneurysm (日) (読)
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| 12. | (英) Mineralocorticoid Receptor Antagonists (日) (読)
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| 13. | (英) NADPH Oxidase (日) (読)
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| 14. | (英) Ovariectomy (日) (読)
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| 15. | 酸化ストレス (oxidative stress)
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| 16. | (英) Peptidyl-Dipeptidase A (日) (読)
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| 17. | (英) RNA, Messenger (日) (読)
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| 18. | (英) Rats (日) (読)
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| 19. | (英) Rats, Sprague-Dawley (日) (読)
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| 20. | (英) Receptors, Mineralocorticoid (日) (読)
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| 21. | レニン·アンジオテンシンシステム (Renin-angiotensin System)
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| 22. | (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読)
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| 23. | (英) Spironolactone (日) (読)
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| 24. | (英) Tyrosine (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Hypertension ([American Heart Association])
(pISSN: 0194-911X, eISSN: 1524-4563)
| ○ISSN (任意): | □ | 1524-4563
ISSN: 0194-911X
(pISSN: 0194-911X, eISSN: 1524-4563) Title: Hypertension (Dallas, Tex. : 1979)Title(ISO): HypertensionPublisher: American Heart Association (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 54
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 552 557
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2009年 7月 20日 (平成 21年 7月 20日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1161/HYPERTENSIONAHA.109.134130 (→Scopusで検索)
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| ○PMID (任意): | □ | 19620512 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1161/HYPERTENSIONAHA.109.134130 (日)
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| 2. | (英) Article.Affiliation: Department of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, Japan. yoshiteru.tada@hotmail.co.jp. (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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