『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=260905EID:260905, Map:0, LastModified:2014年12月26日(金) 20:34:06, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Morishige Junichi (日) (読)
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2.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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3.堀 均
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4. (英) Satouchi Kiyoshi (日) (読)
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5. (英) Yoshiomoto Tanihiro (日) (読)
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6.德村 彰
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題名 (必須): (英) Lysophosphatidic Acid Produced by Hen Egg White Lysophospholipase D Induces Vascular Development on Extraembryonic Membranes  (日)    [継承]
副題 (任意):
要約 (任意): (英) Lysophosphatidic acid (lysoPtdOH), a lysophospholipid mediator, exerts diverse physiological effects, including angiogenesis, through its specific G-protein-coupled receptors. Previously, we showed that unfertilized hen egg white contains polyunsaturated fatty acid-rich lysoPtdOH and lysophospholipase D (lysoPLD). Here, we examined whether lysoPtdOH was produced by lysoPLD in the presence and absence of a hen fertilized ovum and what the physiological role of lysoPtdOH in hen egg white is. Mass spectrometry showed that fertilized hen egg white contained about 8 μM lysoPtdOH before incubation with an ovum, mainly comprised of 18:1- (12.6 %), 18:2- (37.8 %) and 20:4-molecular species (41.5 %). In an early gestation period, the lysoPtdOH was increased up to 9.6 μM, concomitant with a decrease in the level of polyunsaturated lysophosphatidylcholine (lysoPtdCho). Moreover, lysoPtdOH-degrading activities were found in egg white and the vitelline membrane, showing that these enzymes control lysoPtdOH levels in egg white. In an egg yolk angiogenesis assay, two lysoPtdOH receptor antagonists, Ki16425 and N-palmitoyl serine phosphoric acid (NASP), inhibited blood vessel formation induced by exogenously added 18:1-lysoPtdOH and its precursor lysoPtdCho on the hen yolk sac. Ki16425 and NASP also inhibited blood vessel formation in the chorioallantoic membrane (CAM). Furthermore, the relatively higher levels of LPA1, LPA2, LPA4 and LPA6 mRNA were present in the yolk sac and CAM. These results suggest that lysoPtdOH produced from lysoPtdCho by the action of lysoPLD in hen egg white is involved in the formation of blood vessel networks through several lysoPtdOH receptors on various extraembryonic membranes, including the yolk sac membrane and CAM.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Chick Embryo (日) (読) [継承]
3. (英) Chickens (日) (読) [継承]
4. (英) Chorioallantoic Membrane (日) (読) [継承]
5. (英) Egg White (日) (読) [継承]
6. (英) Extraembryonic Membranes (日) (読) [継承]
7. (英) Fertilization (日) (読) [継承]
8. (英) Lysophospholipids (日) (読) [継承]
9. (英) Neovascularization, Physiologic (日) (読) [継承]
10. (英) Ovum (日) (読) [継承]
11. (英) Phosphoric Diester Hydrolases (日) (読) [継承]
12. (英) RNA, Messenger (日) (読) [継承]
13. (英) Receptors, Lysophosphatidic Acid (日) (読) [継承]
14. (英) Yolk Sac (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Lipids ([American Oil Chemists' Society])
(pISSN: 0024-4201, eISSN: 1558-9307)

ISSN (任意): 1558-9307
ISSN: 0024-4201 (pISSN: 0024-4201, eISSN: 1558-9307)
Title: Lipids
Title(ISO): Lipids
Supplier: Springer Online Journal Archive
Publisher: Springer Berlin Heidelberg
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 48 [継承]
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(必須): 251 262 [継承]
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年月日 (必須): 西暦 2013年 2月 6日 (平成 25年 2月 6日) [継承]
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DOI (任意): 10.1007/s11745-013-3765-7    (→Scopusで検索) [継承]
PMID (任意): 23381130    (→Scopusで検索) [継承]
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WOS (任意): 000315274400005 [継承]
Scopus (任意): 2-s2.0-84878376634 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1007/s11745-013-3765-7  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Junichi Morishige, Yoshihiro Uto, Hitoshi Hori, Kiyoshi Satouchi, Tanihiro Yoshiomoto and Akira Tokumura : Lysophosphatidic Acid Produced by Hen Egg White Lysophospholipase D Induces Vascular Development on Extraembryonic Membranes, Lipids, Vol.48, No.3, 251-262, 2013.
欧文冊子 ● Junichi Morishige, Yoshihiro Uto, Hitoshi Hori, Kiyoshi Satouchi, Tanihiro Yoshiomoto and Akira Tokumura : Lysophosphatidic Acid Produced by Hen Egg White Lysophospholipase D Induces Vascular Development on Extraembryonic Membranes, Lipids, Vol.48, No.3, 251-262, 2013.

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