『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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学究種別 (推奨):
組織 (推奨): 1.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域]) [継承]
著者 (必須): 1. (英) Ishiwata Sayuri (日) (読)
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2. (英) Umino Asami (日) (読)
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3. (英) Umino Masakazu (日) (読)
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4.頼田 和子
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5.福井 清 ([徳島大学])
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6. (英) Nishikawa Toru (日) (読)
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題名 (必須): (英) Modulation of extracellular d-serine content by calcium permeable AMPA receptors in rat medial prefrontal cortex as revealed by in vivo microdialysis  (日)    [継承]
副題 (任意):
要約 (任意): (英) In mammalian brains, d-serine has been shown to be required for the regulation of glutamate neurotransmission as an endogenous co-agonist for the N-methyl-d-aspartate type glutamate receptor that is essential for the expression of higher-order brain functions. The exact control mechanisms for the extracellular d-serine dynamics, however, await further elucidation. To obtain an insight into this issue, we have characterized the effects of agents acting at the α-amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid (AMPA) type glutamate receptor on the extracellular d-serine contents in the medial prefrontal cortex of freely moving rats by an in vivo microdialysis technique in combination with high-performance liquid chromatography with fluorometric detection. In vivo experiments are needed in terms of a crucial role of d-serine in the neuron-glia communications despite the previous in vitro studies on AMPA receptor-d-serine interactions using the separated preparations of neurons or glial cells. Here, we show that the intra-cortical infusion of (S)-AMPA, an active enantiomer at the AMPA receptor, causes a significant and concentration-dependent reduction in the prefrontal extracellular contents of d-serine, which is reversed by an AMPA/kainate receptor antagonist, 2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt, and a calcium permeable AMPA receptor antagonist, 1-naphthyl acetyl spermine. The d-serine reducing effects of (S)-AMPA are augmented by co-infusion of cyclothiazide that prevents AMPA receptor desensitization. Our data support the view that a calcium permeable AMPA receptor subtype may exert a phasic inhibitory control on the extracellular d-serine release in the mammalian prefrontal cortex in vivo.  (日)    [継承]
キーワード (推奨):
発行所 (推奨): Cambridge University Press [継承]
誌名 (必須): The International Journal of Neuropsychopharmacology ([Collegium Internationale Neuro-Psychopharmacologicum])
(pISSN: 1461-1457, eISSN: 1469-5111)

ISSN (任意): 1469-5111
ISSN: 1461-1457 (pISSN: 1461-1457, eISSN: 1469-5111)
Title: The international journal of neuropsychopharmacology
Title(ISO): Int. J. Neuropsychopharmacol.
Publisher: Oxford University Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 6 [継承]
(必須): 1395 1406 [継承]
都市 (任意): ケンブリッジ (Cambridge/[連合王国]) [継承]
年月日 (必須): 西暦 2013年 7月 1日 (平成 25年 7月 1日) [継承]
URL (任意):
DOI (任意): 10.1017/S1461145712001484    (→Scopusで検索) [継承]
PMID (任意): 23298512    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1017/S1461145712001484  (日)    [継承]
2.(英) Article.Affiliation: Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Sayuri Ishiwata, Asami Umino, Masakazu Umino, Kazuko YORITA, Kiyoshi Fukui and Toru Nishikawa : Modulation of extracellular d-serine content by calcium permeable AMPA receptors in rat medial prefrontal cortex as revealed by in vivo microdialysis, The International Journal of Neuropsychopharmacology, Vol.16, No.6, 1395-1406, 2013.
欧文冊子 ● Sayuri Ishiwata, Asami Umino, Masakazu Umino, Kazuko YORITA, Kiyoshi Fukui and Toru Nishikawa : Modulation of extracellular d-serine content by calcium permeable AMPA receptors in rat medial prefrontal cortex as revealed by in vivo microdialysis, The International Journal of Neuropsychopharmacology, Vol.16, No.6, 1395-1406, 2013.

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