『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=259868)

EID=259868EID:259868, Map:0, LastModified:2018年5月1日(火) 21:13:52, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[宮本 洋二], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.玉谷 哲也
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2.髙丸 菜都美
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3. (英) Hara Kanae (日) 原 香苗 (読) はら かなえ
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学籍番号 (推奨): **** [ユーザ]
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4. (英) Kinouchi Makoto (日) 木内 誠 (読) きのうち まこと
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学籍番号 (推奨): **** [ユーザ]
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5.栗林 伸行
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6.大江 剛 ([徳島大学.病院.診療科.歯科口腔外科.口腔外科])
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7.内田 大亮
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8.藤澤 健司
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9.永井 宏和
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10.宮本 洋二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔外科学])
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題名 (必須): (英) Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuclear factor B activity in human oral cancer cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Oral cancer cells have a significantly augmented nuclear factor-κB (NF-κB) activity and the inhibition of this activity suppresses tumor growth. Bortezomib is a proteasome inhibitor and a drug used for molecular-targeted therapy (targets NF-κB). In this study, we investigated whether bortezomib would be effective as an inhibitor of proliferation and a radiosensitizer for the treatment of oral cancer. We demonstrate that bortezomib inhibits NF-κB activity and cell proliferation. The combined treatment with bortezomib and radiation (RT) suppressed NF-κB activity and cell growth in vitro and in vivo compared with RT treatment alone. To investigate the mechanisms by which bortezomib suppresses tumor growth, the expression of signaling molecules downstream of NF-κB were examined by ELISA. The combined treatment significantly inhibited the radiation-induced production of angiogenic factors and decreased the number of blood vessels in the tumor tissues. Although the expression of anti-apoptotic proteins was upregulated by RT, bortezomib downregulated the RT-induced expression of these proteins. Moreover, the expression of cleaved poly(ADP-ribose) polymerase in vitro and in vivo was enhanced by bortezomib, indicating that bortezomib inhibits tumor growth by inducing apoptosis. This study clearly demonstrates that bortezomib significantly inhibits tumor growth and that the combined treatment with bortezomib and RT results in a significant inhibition of tumor growth. The mechanisms underlying the inhibition of tumor growth by bortezomib include the suppression of angiogenesis and the induction of apoptosis. A novel molecular targeting therapy including bortezomib may be effective in the treatment of oral cancer by suppressing NF-κB activity.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antineoplastic Agents (日) (読) [継承]
3. (英) Apoptosis (日) (読) [継承]
4. (英) Boronic Acids (日) (読) [継承]
5. (英) Cell Line, Tumor (日) (読) [継承]
6. (英) Cell Proliferation (日) (読) [継承]
7. (英) Female (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) I-kappa B Proteins (日) (読) [継承]
10. (英) Interleukin-6 (日) (読) [継承]
11. (英) Interleukin-8 (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Mice, Inbred BALB C (日) (読) [継承]
14. (英) Mice, Nude (日) (読) [継承]
15. (英) Mouth Neoplasms (日) (読) [継承]
16. (英) NF-kappa B (日) (読) [継承]
17. (英) Neoplasm Transplantation (日) (読) [継承]
18. (英) Neovascularization, Pathologic (日) (読) [継承]
19. (英) Poly(ADP-ribose) Polymerases (日) (読) [継承]
20. (英) Pyrazines (日) (読) [継承]
21. (英) Radiation-Sensitizing Agents (日) (読) [継承]
22. (英) Transcription Factor RelA (日) (読) [継承]
23. (英) Vascular Endothelial Growth Factor A (日) (読) [継承]
24. (英) Xenograft Model Antitumor Assays (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Oncology (International Center for Cancer Research)
(pISSN: 1019-6439, eISSN: 1791-2423)

ISSN (任意): 1791-2423
ISSN: 1019-6439 (pISSN: 1019-6439, eISSN: 1791-2423)
Title: International journal of oncology
Title(ISO): Int. J. Oncol.
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 42 [継承]
(必須): 3 [継承]
(必須): 935 944 [継承]
都市 (任意):
年月日 (必須): 西暦 2013年 3月 初日 (平成 25年 3月 初日) [継承]
URL (任意):
DOI (任意): 10.3892/ijo.2013.1786    (→Scopusで検索) [継承]
PMID (任意): 23340716    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.3892/ijo.2013.1786  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tetsuya Tamatani, Natsumi Takamaru, Kanae Hara, Makoto Kinouchi, Nobuyuki Kuribayashi, Go Ohe, Daisuke Uchida, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuclear factor B activity in human oral cancer cells., International Journal of Oncology, Vol.42, No.3, 935-944, 2013.
欧文冊子 ● Tetsuya Tamatani, Natsumi Takamaru, Kanae Hara, Makoto Kinouchi, Nobuyuki Kuribayashi, Go Ohe, Daisuke Uchida, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuclear factor B activity in human oral cancer cells., International Journal of Oncology, Vol.42, No.3, 935-944, 2013.

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