『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=259867EID:259867, Map:0, LastModified:2018年4月5日(木) 14:39:00, Operator:[三好 小文], Avail:TRUE, Censor:0, Owner:[宮本 洋二], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.玉谷 哲也
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2. (英) Ferdous Tarannum (日) (読)
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3.髙丸 菜都美
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4. (英) Hara Kanae (日) 原 香苗 (読) はら かなえ
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学籍番号 (推奨): **** [ユーザ]
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5. (英) Kinouchi Makoto (日) 木内 誠 (読) きのうち まこと
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学籍番号 (推奨): **** [ユーザ]
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6.栗林 伸行
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7.大江 剛 ([徳島大学.病院.診療科.歯科口腔外科.口腔外科])
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8.内田 大亮
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9.永井 宏和
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10.藤澤 健司
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11.宮本 洋二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔外科学])
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題名 (必須): (英) Antitumor efficacy of sequential treatment with docetaxel and 5-fluorouracil against human oral cancer cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) Docetaxel (DOC) and 5-fluorouracil (5-FU) are important anticancer agents widely used in the treatment of a variety of cancers including oral squamous cell carcinoma (OSCC). The purpose of this study was to determine the antitumor efficacy of the sequential administration of DOC and 5-FU against OSCC cells (B88 and CAL27 cells) in vitro and in vivo. In in vitro growth inhibition assays, sequential treatment with DOC followed by 5-FU was more effective in inhibiting cancer cell growth than 5-FU followed by DOC, single treatment with DOC or 5-FU, or combined treatment with DOC and 5-FU. Furthermore, DOC followed by 5-FU significantly inhibited tumor growth in vivo compared to 5-FU followed by DOC. To understand the mechanisms underlying the enhanced growth inhibitory effect of the administration sequence, DOC followed by 5-FU, we examined the expression of 5-FU metabolic enzymes such as thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT), which were known to regulate the antitumor effect of 5-FU, by real-time RT-PCR and western blot analysis. Downregulation of TS and DPD expression and upregulation of OPRT expression were induced by DOC treatment, suggesting that DOC enhanced the efficacy of 5-FU by altering the expression of its metabolic enzymes. These results indicate that sequential treatment with DOC followed by 5-FU could be a promising therapeutic strategy for oral cancer.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antineoplastic Combined Chemotherapy Protocols (日) (読) [継承]
3. (英) Cell Line, Tumor (日) (読) [継承]
4. (英) Dihydrouracil Dehydrogenase (NADP) (日) (読) [継承]
5. (英) Down-Regulation (日) (読) [継承]
6. (英) Fluorouracil (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Mice, Nude (日) (読) [継承]
10. (英) Mouth Neoplasms (日) (読) [継承]
11. (英) Orotate Phosphoribosyltransferase (日) (読) [継承]
12. (英) Taxoids (日) (読) [継承]
13. (英) Thymidylate Synthase (日) (読) [継承]
14. (英) Up-Regulation (日) (読) [継承]
15. (英) Xenograft Model Antitumor Assays (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Oncology (International Center for Cancer Research)
(pISSN: 1019-6439, eISSN: 1791-2423)

ISSN (任意): 1791-2423
ISSN: 1019-6439 (pISSN: 1019-6439, eISSN: 1791-2423)
Title: International journal of oncology
Title(ISO): Int. J. Oncol.
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 41 [継承]
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(必須): 1148 1156 [継承]
都市 (任意):
年月日 (必須): 西暦 2012年 9月 初日 (平成 24年 9月 初日) [継承]
URL (任意):
DOI (任意): 10.3892/ijo.2012.1544    (→Scopusで検索) [継承]
PMID (任意): 22766915    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.3892/ijo.2012.1544  (日)    [継承]
2.(英) Article.Affiliation: Department of Oral Surgery, Subdivision of Molecular Oral Medicine, Division of Integrated Sciences of Translational Research, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8504, Japan. ttama@dent.tokushima-u.ac.jp  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tetsuya Tamatani, Tarannum Ferdous, Natsumi Takamaru, Kanae Hara, Makoto Kinouchi, Nobuyuki Kuribayashi, Go Ohe, Daisuke Uchida, Hirokazu Nagai, Kenji Fujisawa and Youji Miyamoto : Antitumor efficacy of sequential treatment with docetaxel and 5-fluorouracil against human oral cancer cells, International Journal of Oncology, Vol.41, No.3, 1148-1156, 2012.
欧文冊子 ● Tetsuya Tamatani, Tarannum Ferdous, Natsumi Takamaru, Kanae Hara, Makoto Kinouchi, Nobuyuki Kuribayashi, Go Ohe, Daisuke Uchida, Hirokazu Nagai, Kenji Fujisawa and Youji Miyamoto : Antitumor efficacy of sequential treatment with docetaxel and 5-fluorouracil against human oral cancer cells, International Journal of Oncology, Vol.41, No.3, 1148-1156, 2012.

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