『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=259759)

EID=259759EID:259759, Map:0, LastModified:2013年7月1日(月) 09:48:30, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[佐田 政隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.島袋 充生
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[継承]
2. (英) Hirata, Y. (日) (読)
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[継承]
3. (英) Tabata, M. (日) (読)
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[継承]
4. (英) Dagvasumberel, M. (日) (読)
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[継承]
5. (英) Sato, H. (日) (読)
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[継承]
6.黒部 裕嗣
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[継承]
7.福田 大受 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).心臓血管病態医学])
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[継承]
8.添木 武 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学]/[徳島大学.病院.診療科.内科.循環器内科])
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学籍番号 (推奨):
[継承]
9.北川 哲也
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学籍番号 (推奨):
[継承]
10. (英) Takanashi, S. (日) (読)
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[継承]
11.佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The impact of epicardial adipose tissue (EAT) over abdominal or overall adiposity on coronary artery disease (CAD) is currently unknown. We compared the association among EAT volume (EATV), cytokine/adipocytokine profiles in EAT and subcutaneous fat, and atherogenic CAD. APPROACH AND RESULTS: Paired samples were obtained from EAT and subcutaneous adipose tissue during elective cardiac surgery for CAD (n=50) or non-CAD (n=50). EATV was the sum of cross-sectional EAT areas, and visceral and subcutaneous fat areas were determined at the umbilicus level on computed tomography scans. CD68(+), CD11c(+), and CD206(+) cells were counted using immunohistochemical staining. Cytokine/adipocytokine expression was evaluated using quantitative real-time polymerase chain reaction. Multivariate analysis indicated that male sex, age, diabetes mellitus, high triglycerides, and low high-density lipoprotein cholesterol, and EATV index (EATV/body surface area, cm(3)/m(2)) were significant CAD predictors (corrected R(2)=0.401; P<0.001); visceral fat area, hypertension, smoking, low-density lipoprotein cholesterol (140 mg/dL [3.63 mmol/L]) or statin use were not predictors. The EATV index positively correlated with the CD68(+) and CD11c(+) cell numbers and nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3), interleukin-1β, and interleukin-1R expression; and negatively correlated with adiponectin expression in EAT. A multivariate analysis model, including CD68(+) cells and interleukin-1β, and adiponectin expression in EAT strongly predicted CAD (corrected R(2)=0.756; P<0.001). EATV and macrophage and cytokine/adipocytokine signals in EAT strongly correlated with CAD. Our findings suggest that EATV and adipocytokine imbalance are strongly linked to human coronary atherosclerosis.  (日)    [継承]
キーワード (推奨): 1. (英) Adipokines (日) (読) [継承]
2. (英) Adipose Tissue (日) (読) [継承]
3. (英) Aged (日) (読) [継承]
4. (英) Antigens, CD (日) (読) [継承]
5. (英) Antigens, CD11c (日) (読) [継承]
6. (英) Antigens, Differentiation, Myelomonocytic (日) (読) [継承]
7. (英) Cholesterol, HDL (日) (読) [継承]
8. (英) Coronary Artery Disease (日) (読) [継承]
9. (英) Female (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Logistic Models (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Middle Aged (日) (読) [継承]
14. (英) Pericardium (日) (読) [継承]
発行所 (推奨): American Heart Association [継承]
誌名 (必須): Arteriosclerosis, Thrombosis, and Vascular Biology ([American Heart Association])
(pISSN: 1079-5642, eISSN: 1524-4636)

ISSN (任意): 1524-4636
ISSN: 1079-5642 (pISSN: 1079-5642, eISSN: 1524-4636)
Title: Arteriosclerosis, thrombosis, and vascular biology
Title(ISO): Arterioscler. Thromb. Vasc. Biol.
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 33 [継承]
(必須): 5 [継承]
(必須): 1077 1084 [継承]
都市 (任意):
年月日 (必須): 西暦 2013年 3月 7日 (平成 25年 3月 7日) [継承]
URL (任意):
DOI (任意): 10.1161/ATVBAHA.112.300829    (→Scopusで検索) [継承]
PMID (任意): 23471228    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1161/ATVBAHA.112.300829  (日)    [継承]
2.(英) Article.Affiliation: Department of Cardio-Diabetes Medicine, The University of Tokushima Graduate School of Health Biosciences, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. mshimabukuro-ur@umin.ac.jp  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Michio Shimabukuro, Y. Hirata, M. Tabata, M. Dagvasumberel, H. Sato, Hirotsugu Kurobe, Daiju Fukuda, Takeshi Soeki, Tetsuya Kitagawa, S. Takanashi and Masataka Sata : Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis., Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.33, No.5, 1077-1084, 2013.
欧文冊子 ● Michio Shimabukuro, Y. Hirata, M. Tabata, M. Dagvasumberel, H. Sato, Hirotsugu Kurobe, Daiju Fukuda, Takeshi Soeki, Tetsuya Kitagawa, S. Takanashi and Masataka Sata : Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis., Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.33, No.5, 1077-1084, 2013.

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