『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=259165)

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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない)) [継承]
学究種別 (推奨): 博士課程学生による研究報告 [継承]
組織 (推奨): 1.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域]) [継承]
著者 (必須): 1. (英) Kim Mi Sun (日) 金 善美 (読)
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2.坂井 隆志
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3. (英) Dang Van Huy (日) ダン ヴァン フイ (読) だん ゔぁん ふぃー
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学籍番号 (推奨): **** [ユーザ]
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4.チャン ホアンナム ([徳島大学.高等教育研究センター.学修支援部門]/[徳島大学.国際センター])
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5.小野 公嗣
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6.石村 和敬
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7.福井 清 ([徳島大学])
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題名 (必須): (英) Nucling, a novel protein associated with NF-B, regulates endotoxin-induced apoptosis in vivo  (日)    [継承]
副題 (任意):
要約 (任意): (英) Nucling is a proapoptotic protein that regulates the apoptosome and nuclear factor-kappa B (NF-B) signalling pathways. Strong stimuli, such as Gram-negative bacterial lipopolysaccharide (LPS), induce the simultaneous secretion of cytokines following the activation of NF-B. Proinflammatory cytokines can induce liver damage through several mechanisms such as increases in oxidative stress and apoptotic reactions leading to tissue necrosis. Herein, we show that Nucling-knockout (KO) mice are resistant to LPS that consistently caused mortality in wild-type (WT) counterparts. Although serum levels of cytokines such as tumour necrosis factor (TNF)-, interleukin (IL)-1 and IL-6 did not differ significantly between WT and Nucling-KO mice after the LPS challenge, hepatocytes of Nucling-KO mice were refractory to LPS- or TNF--induced cell death. These results were consistent with the decreased expression of proapoptotic proteins including apoptosis-inducing factor and cleaved form of poly (ADP-ribose) polymerase and terminal deoxynucleotidyl transferase dUTP nick end-labelling positive cells in the liver of Nucling-KO mice after the administration of a lethal dose of LPS. Moreover, the upregulation of NF-B-regulated anti-apoptotic molecules including cellular inhibitor of apoptosis (cIAP) 1 and cIAP2 was observed in the liver of Nucling-KO mice after LPS treatment. These findings indicate that the Nucling deficiency leads to resistance to apoptosis in liver. We propose that Nucling is important for the induction of apoptosis in cells damaged by cytotoxic stressors through the NF-B signalling pathway.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2.アポトーシス (apoptosis) [継承]
3. (英) Apoptosis Regulatory Proteins (日) (読) [継承]
4. (英) Cells, Cultured (日) (読) [継承]
5.細胞質分裂 (cytokinesis) [継承]
6. (英) Disease Resistance (日) (読) [継承]
7. (英) Down-Regulation (日) (読) [継承]
8. (英) Endotoxins (日) (読) [継承]
9. (英) Hepatocytes (日) (読) [継承]
10. (英) Kupffer Cells (日) (読) [継承]
11. (英) Male (日) (読) [継承]
12. (英) Membrane Proteins (日) (読) [継承]
13. (英) Mice (日) (読) [継承]
14.ノックアウトマウス (knockout mice) [継承]
15. (英) NF-kappa B (日) (読) [継承]
16. (英) Shock, Septic (日) (読) [継承]
17.シグナル伝達 (signal transduction) [継承]
18. (英) Specific Pathogen-Free Organisms (日) (読) [継承]
19. (英) Survival Analysis (日) (読) [継承]
20. (英) Survival Rate (日) (読) [継承]
21. (英) Up-Regulation (日) (読) [継承]
発行所 (推奨): 日本生化学会 [継承]
誌名 (必須): The Journal of Biochemistry ([日本生化学会])
(pISSN: 0021-924X, eISSN: 1756-2651)

ISSN (任意): 1756-2651
ISSN: 0021-924X (pISSN: 0021-924X, eISSN: 1756-2651)
Title: Journal of biochemistry
Title(ISO): J. Biochem.
Supplier: Oxford University Press
Publisher: Oxford University Press
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 153 [継承]
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(必須): 93 101 [継承]
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年月日 (必須): 西暦 2013年 1月 1日 (平成 25年 1月 1日) [継承]
URL (任意):
DOI (任意): 10.1093/jb/mvs119    (→Scopusで検索) [継承]
PMID (任意): 23071121    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-84871630704 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Sun Mi Kim, Takashi Sakai, Huy Van Dang, HoangNam Tran, Koji Ono, Kazunori Ishimura and Kiyoshi Fukui : Nucling, a novel protein associated with NF-B, regulates endotoxin-induced apoptosis in vivo, The Journal of Biochemistry, Vol.153, No.1, 93-101, 2013.
欧文冊子 ● Sun Mi Kim, Takashi Sakai, Huy Van Dang, HoangNam Tran, Koji Ono, Kazunori Ishimura and Kiyoshi Fukui : Nucling, a novel protein associated with NF-B, regulates endotoxin-induced apoptosis in vivo, The Journal of Biochemistry, Vol.153, No.1, 93-101, 2013.

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