『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=259011EID:259011, Map:0, LastModified:2020年4月22日(水) 17:17:08, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[松久 宗英], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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著者 (必須): 1. (英) Katakami Naoto (日) (読)
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2. (英) Kaneto Hideaki (日) (読)
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3. (英) Sakamoto Fumie (日) (読)
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4. (英) Takahara Mitsuyoshi (日) (読)
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5. (英) Irie Yoko (日) (読)
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6. (英) Fujisawa Keiko (日) (読)
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7. (英) Miyashita Kazuyuki (日) (読)
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8. (英) Yasuda Tetsuyuki (日) (読)
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9. (英) Matsuoka Taka-Aki (日) (読)
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10. (英) Yoshiuchi Kazutomi (日) (読)
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11. (英) Sakamoto Ken'ya (日) (読)
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12.黒田 暁生 ([徳島大学.先端酵素学研究所.基幹研究部門])
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13.松久 宗英 ([徳島大学.先端酵素学研究所.基幹研究部門]/徳島大学病院アンチエイジングセンター センター長(併任))
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14. (英) Kosugi Keisuke (日) (読)
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15. (英) Shimomura Iichiro (日) (読)
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題名 (必須): (英) Plasma pentraxin 3 levels are associated with carotid IMT in type 1 diabetic patients.  (日)    [継承]
副題 (任意):
要約 (任意): (英) AIMS: Pentraxin3 (PTX3), a recently discovered inflammatory mediator, is produced abundantly in various cells in atherosclerotic lesions, and therefore, its plasma level could reflect local inflammation at the site of atherosclerotic lesion. The present study evaluated whether plasma PTX3 levels are associated with subclinical atherosclerosis in young subjects with type 1 diabetes. METHODS: Plasma PTX3 levels, urinary albumin excretion, diabetic retinopathy, and carotid intima-media thickness (IMT) were examined in 78 Japanese type 1 diabetic patients (30 men and 48 women, aged 28.5±5.3 years (±SD), duration of diabetes 19.7±6.5 years). RESULTS: There was statistically significant association between plasma PTX3 levels and Max-IMT (r=0.363, p=0.001). A stepwise multivariate regression analysis including conventional coronary risk factors as independent variables revealed that plasma PTX3 levels (=0.389, p<0.001), duration of diabetes (=0.256, p=0.035), and serum triglyceride levels (=0.371, p<0.001) were independent determinants of Max-IMT. In addition, plasma PTX3 levels was an independent determinant of urinary albumin excretion, an indicator of diabetic nephropathy (=0.258, p=0.018). However, there was no significant association between plasma PTX3 levels and diabetic retinopathy. CONCLUSIONS: Increased levels of plasma PTX3 are associated with accelerated atherosclerotic change and increased albuminuria in young patients with type 1 diabetes.  (日)    [継承]
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誌名 (必須): Diabetes Research and Clinical Practice (International Diabetes Federation)
(pISSN: 0168-8227, eISSN: 1872-8227)

ISSN (任意): 1872-8227
ISSN: 0168-8227 (pISSN: 0168-8227, eISSN: 1872-8227)
Title: Diabetes research and clinical practice
Title(ISO): Diabetes Res Clin Pract
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2013年 2月 末日 (平成 25年 2月 末日) [継承]
URL (任意):
DOI (任意): 10.1016/j.diabres.2012.11.020    (→Scopusで検索) [継承]
PMID (任意): 23245734    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan; Department of Metabolism and Atherosclerosis, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: katakami@medone.med.osaka-u.ac.jp.  (日)    [継承]
2.(英) PublicationType: JOURNAL ARTICLE  (日)    [継承]

標準的な表示

和文冊子 ● Naoto Katakami, Hideaki Kaneto, Fumie Sakamoto, Mitsuyoshi Takahara, Yoko Irie, Keiko Fujisawa, Kazuyuki Miyashita, Tetsuyuki Yasuda, Taka-Aki Matsuoka, Kazutomi Yoshiuchi, Ken'ya Sakamoto, Akio Kuroda, Munehide Matsuhisa, Keisuke Kosugi and Iichiro Shimomura : Plasma pentraxin 3 levels are associated with carotid IMT in type 1 diabetic patients., Diabetes Research and Clinical Practice, Vol.99, No.2, 185-91, 2013.
欧文冊子 ● Naoto Katakami, Hideaki Kaneto, Fumie Sakamoto, Mitsuyoshi Takahara, Yoko Irie, Keiko Fujisawa, Kazuyuki Miyashita, Tetsuyuki Yasuda, Taka-Aki Matsuoka, Kazutomi Yoshiuchi, Ken'ya Sakamoto, Akio Kuroda, Munehide Matsuhisa, Keisuke Kosugi and Iichiro Shimomura : Plasma pentraxin 3 levels are associated with carotid IMT in type 1 diabetic patients., Diabetes Research and Clinical Practice, Vol.99, No.2, 185-91, 2013.

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