『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
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カテゴリ (推奨): 研究 [継承]
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著者 (必須): 1.鳥羽 博明 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学])
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[継承]
2.先山 正二
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[継承]
3.監﨑 孝一郎
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[継承]
4.川上 行奎 ([徳島大学.病院.中央診療施設等.地域外科診療部])
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[継承]
5. (英) Uyama Koh (日) (読)
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[継承]
6.坂東 良美 ([徳島大学.病院.中央診療施設等.病理部])
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学籍番号 (推奨):
[継承]
7.丹黒 章 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Implantation of fetal rat lung fragments into bleomycin-induced pulmonary fibrosis  (日)    [継承]
副題 (任意):
要約 (任意): (英) Pulmonary fibrosis is a life-threatening disease that results in progressive respiratory failure. We have suggested the possibility of fetal lung tissue as an option for further investigation into lung regeneration. The objective was to prove whether fetal lung fragments can survive and differentiate in fibrotic lung. Lewis rats were administered bleomycin and used as recipients after 3 or 4 weeks. Day 17 fetal lung tissue from green fluorescent protein Lewis rats was used as donor material. Donor lungs were removed, cut into small pieces, and implanted into the recipients' left lung. The recipients received cyclosporin to prevent immune response to green fluorescent protein and were killed after 1, 2, 4, 8, and 12 weeks and histologically evaluated. Furthermore, the expression of thyroid transcription factor-1 and Clara cell secretory protein in the implanted fetal lung tissue was immunohistologically evaluated. Fibrotic changes were recognized for a long period of time in the recipient lungs. The implanted fetal lung fragments could be clearly distinguished from recipient lungs because of the luminescence of grafts. Fetal lung fragments could survive in the recipient lungs with fibrotic changes. The air spaces of implanted fetal lungs were narrow at 1 and 2 weeks but expanded with the passage of time. The connection between the recipient lung and the implanted fetal lung was recognized, particularly in the peripheral grafts. The expression patterns of thyroid transcription factor-1 and Clara cell secretory protein in implanted lungs resembled those in the process of normal lung morphogenesis. Fetal rat lung fragments could survive and differentiate in bleomycin-induced completely fibrotic lung.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Animals, Genetically Modified (日) (読) [継承]
3. (英) Bleomycin (日) (読) [継承]
4.細胞分化 (cell differentiation) [継承]
5. (英) Disease Models, Animal (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Graft Survival (日) (読) [継承]
8. (英) Green Fluorescent Proteins (日) (読) [継承]
9.免疫組織化学 (immunohistochemistry) [継承]
10. (英) Lung (日) (読) [継承]
11. (英) Lung Transplantation (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Nuclear Proteins (日) (読) [継承]
14.肺線維症 (pulmonary fibrosis) [継承]
15. (英) Rats (日) (読) [継承]
16. (英) Rats, Inbred Lew (日) (読) [継承]
17.再生 (regeneration) [継承]
18. (英) Time Factors (日) (読) [継承]
19. (英) Transcription Factors (日) (読) [継承]
20. (英) Uteroglobin (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Thoracic and Cardiovascular Surgery (American Association for Thoracic Surgery)
(pISSN: 0022-5223, eISSN: 1097-685X)

ISSN (任意): 1097-685X
ISSN: 0022-5223 (pISSN: 0022-5223, eISSN: 1097-685X)
Title: The Journal of thoracic and cardiovascular surgery
Title(ISO): J Thorac Cardiovasc Surg
Publisher: Mosby Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 143 [継承]
(必須): 6 [継承]
(必須): 1429 1435 [継承]
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年月日 (必須): 西暦 2012年 2月 2日 (平成 24年 2月 2日) [継承]
URL (任意):
DOI (任意): 10.1016/j.jtcvs.2012.01.002    (→Scopusで検索) [継承]
PMID (任意): 22305550    (→Scopusで検索) [継承]
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WOS (任意): 000304110700030 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.jtcvs.2012.01.002  (日)    [継承]
2.(英) Article.Affiliation: Department of Thoracic and Endocrine Surgery, The University of Tokushima, Kuramoto-cho, Tokushima, Japan.  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Hiroaki Toba, Shoji Sakiyama, Koichiro Kenzaki, Yukikiyo Kawakami, Koh Uyama, Yoshimi Bando and Akira Tangoku : Implantation of fetal rat lung fragments into bleomycin-induced pulmonary fibrosis, Journal of Thoracic and Cardiovascular Surgery, Vol.143, No.6, 1429-1435, 2012.
欧文冊子 ● Hiroaki Toba, Shoji Sakiyama, Koichiro Kenzaki, Yukikiyo Kawakami, Koh Uyama, Yoshimi Bando and Akira Tangoku : Implantation of fetal rat lung fragments into bleomycin-induced pulmonary fibrosis, Journal of Thoracic and Cardiovascular Surgery, Vol.143, No.6, 1429-1435, 2012.

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