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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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著者 (必須): 1. (英) Satoh, Keitaro (日) 佐藤 慶太郎 (読) さとう けいたろう
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2. (英) Seo, Yoshiteru (日) 瀬尾 義輝 (読) せお よしてる
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3. (英) Matsuo, Shinsuke (日) 松尾 真介 (読) まつお しんすけ
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4. (英) Karabasil, Ratko, Mileva (日) Karabasil, Ratko, Mileva (読) からばしる らとこ みれーば
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5. (英) Matsuki-Fukushima, Miwako (日) 松木-福島 美和子 (読) まつき ふくしま みわこ
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6. (英) Nakahari, Takashi (日) 中張 隆司 (読) なかはり たかし
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7.細井 和雄
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題名 (必須): (英) Roles of AQP5/AQP5-G103D in carbamylcholine-induced volume decrease and in reduction of the activation energy for water transport by rat parotid acinar cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) In order to assess the contribution of the water channel aquaporin-5 (AQP5) to water transport by salivary gland acinar cells, we measured the cell volume and activation energy (E (a)) of diffusive water permeability in isolated parotid acinar cells obtained from AQP5-G103D mutant and their wild-type rats. Immunohistochemistry showed that there was no change induced by carbamylcholine (CCh; 1 μM) in the AQP5 detected in the acinar cells in the wild-type rat. Acinar cells from mutant rats, producing low levels of AQP5 in the apical membrane, showed a minimal increase in the AQP5 due to the CCh. In the wild-type rat, CCh caused a transient swelling of the acinus, followed by a rapid agonist-induced cell shrinkage, reaching a plateau at 30 s. In the mutant rat, the acinus did not swell by CCh challenge, and the agonist-induced cell shrinkage was delayed by 8 s, reaching a transient minimum at around 1 min, and recovered spontaneously even though CCh was persistently present. In the unstimulated wild-type acinar cells, E (a) was 3.4 ± 0.6 kcal mol(-1) and showed no detectable change after CCh stimulation. In the unstimulated mutant acinar cells, high E (a) value (5.9 ± 0.1 kcal mol(-1)) was detected and showed a minimal decrease after CCh stimulation (5.0 ± 0.3 kcal mol(-1)). These results suggested that AQP5 was the main pathway for water transport in the acinar cells and that it was responsible for the rapid agonist-induced acinar cell shrinkage and also necessary to keep the acinar cell volume reduced during the steady secretion in the wild-type rat.  (日)    [継承]
キーワード (推奨): 1. (英) Acinar Cells (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Aquaporin 5 (日) (読) [継承]
4. (英) Carbachol (日) (読) [継承]
5. (英) Cell Membrane Permeability (日) (読) [継承]
6. (英) Cell Size (日) (読) [継承]
7. (英) Mutation (日) (読) [継承]
8. (英) Parotid Gland (日) (読) [継承]
9. (英) Rats (日) (読) [継承]
10. (英) Rats, Mutant Strains (日) (読) [継承]
11. (英) Water (日) (読) [継承]
発行所 (推奨): Springer-Verlag [継承]
誌名 (必須): Pflügers Archiv : European Journal of Physiology ([Springer-Verlag])
(pISSN: 0031-6768, eISSN: 1432-2013)

ISSN (任意): 0031-6768
ISSN: 0031-6768 (pISSN: 0031-6768, eISSN: 1432-2013)
Title: Pflugers Archiv : European journal of physiology
Title(ISO): Pflugers Arch
Supplier: Springer Online Journal Archive
Publisher: Springer Berlin Heidelberg
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(必須): 464 [継承]
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年月日 (必須): 西暦 2012年 10月 初日 (平成 24年 10月 初日) [継承]
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DOI (任意): 10.1007/s00424-012-1141-8    (→Scopusで検索) [継承]
PMID (任意): 22903161    (→Scopusで検索) [継承]
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WOS (任意): 000309178600005 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Regulatory Physiology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, 321-0293, Japan. k-satoh@dokkyomed.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Keitaro Satoh, Yoshiteru Seo, Shinsuke Matsuo, Mileva Ratko Karabasil, Miwako Matsuki-Fukushima, Takashi Nakahari and Kazuo Hosoi : Roles of AQP5/AQP5-G103D in carbamylcholine-induced volume decrease and in reduction of the activation energy for water transport by rat parotid acinar cells, Pflügers Archiv : European Journal of Physiology, Vol.464, No.4, 375-389, 2012.
欧文冊子 ● Keitaro Satoh, Yoshiteru Seo, Shinsuke Matsuo, Mileva Ratko Karabasil, Miwako Matsuki-Fukushima, Takashi Nakahari and Kazuo Hosoi : Roles of AQP5/AQP5-G103D in carbamylcholine-induced volume decrease and in reduction of the activation energy for water transport by rat parotid acinar cells, Pflügers Archiv : European Journal of Physiology, Vol.464, No.4, 375-389, 2012.

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