| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Sakamoto Fumie (日) (読)
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| 2. | (英) Katakami Naoto (日) (読)
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| 3. | (英) Kaneto Hideaki (日) (読)
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| 4. | (英) Yasuda Tetsuyuki (日) (読)
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| 5. | (英) Takahara Mitsuyoshi (日) (読)
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| 6. | (英) Miyashita Kazuyuki (日) (読)
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| 7. | 黒田 暁生 ([徳島大学.先端酵素学研究所.基幹研究部門])
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| 8. | 松久 宗英 ([徳島大学.先端酵素学研究所.基幹研究部門]/徳島大学病院アンチエイジングセンター センター長(併任))
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| 9. | (英) Kosugi Keisuke (日) (読)
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| 10. | (英) Shimomura Iichiro (日) (読)
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| ○題名 (必須): | □ | (英) Association of serum YKL-40 levels with urinary albumin excretion rate in young Japanese patients with type 1 diabetes mellitus. (日)
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| ○要約 (任意): | □ | (英) YKL-40 is a marker of inflammation and endothelial dysfunction, both of which play important roles in the progression of diabetic complications. However, little information has been obtained about serum YKL-40 levels in type 1 diabetic patients. We evaluated YKL-40 levels and its association with diabetic micro- and macroandgiopathy in 131 young Japanese type 1 diabetic patients without advanced diabetic complications (aged 24.7±5.9 years) and 97 age- and gender-matched healthy controls. YKL-40 levels were significantly elevated in type 1 diabetic patients than in healthy controls (median (range) 46.4 (20.3-136.7) and 52.3 (21.4-274.1) ng/ml, respectively, p = 0.006). There was a significant positive association between YKL-40 levels and urinary albumin creatinine ratio (UACR) (r = 0.226, p = 0.013). Furthermore, a multivariate regression analysis demonstrated that YKL-40 levels were a determinant of UACR independently of conventional risk factors. In addition, YKL-40 levels were significantly higher in participants with diabetic retinopathy compared to those without it (median (range) 55.5 (23.3-274.1) and 50.3 (21.4-237.4) ng/ml, respectively, p = 0.039). Serum YKL-40 levels were elevated in type 1 diabetic patients and associated with increasing level of albuminuria. YKL-40 could be a predictor to assess the risk of diabetic microangiopathy in the early stage in type 1 diabetic patients. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Endocrine Journal ([社団法人 日本内分泌学会])
(pISSN: 0918-8959, eISSN: 1348-4540)
| ○ISSN (任意): | □ | 1348-4540
ISSN: 0918-8959
(pISSN: 0918-8959, eISSN: 1348-4540) Title: Endocrine journalTitle(ISO): Endocr JSupplier: 一般社団法人 日本内分泌学会Publisher: Japan Endocrine Sociey/Nihon Naibunpi Gakkai (NLM Catalog)
(医中誌Web)
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| ○巻 (必須): | □ | 60
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 73 79
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2013年 1月 末日 (平成 25年 1月 末日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1507/endocrj.EJ12-0238 (→Scopusで検索)
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| ○PMID (任意): | □ | 22986489 (→Scopusで検索)
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| ○WOS (任意): | □ | 000319027800009
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| ○備考 (任意): | 1. | (英) Affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita 565-0871, Japan. (日)
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| 2. | (英) PublicationType: JOURNAL ARTICLE (日)
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