| ○種別 (必須): |
| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Snapinn W. Katherine (日) (読)
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| 2. | (英) Larson B. Eric (日) (読)
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| 3. | (英) Kawakami Hideshi (日) (読)
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| 4. | (英) Ujike Hiroshi (日) (読)
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| 5. | (英) Borenstein R. Amy (日) (読)
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| 6. | (英) Izumi Yuishin (日) (読)
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| 7. | 梶 龍兒 ([徳島大学.研究支援・産官学連携センター])
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| 8. | (英) Maruyama Hirofumi (日) (読)
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| 9. | (英) Mata F. Ignacio (日) (読)
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| 10. | (英) Morino Hiroyuki (日) (読)
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| ○学籍番号 (推奨): |
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| 11. | (英) Oda Masaya (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 12. | (英) Tsuang W. Debby (日) (読)
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| ○貢献度 (任意): |
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| 13. | (英) Yearout Dora (日) (読)
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| ○貢献度 (任意): |
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| [継承] |
| 14. | (英) Edwards L. Karen (日) (読)
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| ○貢献度 (任意): |
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| [継承] |
| 15. | (英) Zabetian P. Cyrus (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) The UCHL1 S18Y polymorphism and Parkinson's disease in a Japanese population. (日)
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| ○要約 (任意): | □ | (英) UCHL1 plays an important role in the ubiquitin-proteasome system and is a biologically plausible candidate gene for Parkinson's disease (PD). However, results from genetic association studies of the UCHL1 S18Y polymorphism have been equivocal. Meta-analyses indicate that the polymorphism's risk effect might be restricted to Asian populations and early-onset disease. To further explore the role of UCHL1 in PD, we genotyped S18Y in 605 PD patients and 1620 controls of Japanese ancestry. We did not find evidence of an association in the overall sample (SY vs. SS: adjusted OR=1.11, P=0.37; YY vs. SS: adjusted OR=1.01, P=0.94). In the early-onset stratum, however, we observed a trend toward a reduction in risk for those with the Y allele (SY vs. SS, adjusted OR, 0.75; 95% CI, 0.47-1.20; YY vs. SS, OR, 0.64; 95% CI, 0.36-1.14; trend test, P=0.12). These results indicate that, if involved in PD, the S18Y variant is not a major determinant of risk and its effect might be restricted to early-onset disease. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Asian Continental Ancestry Group (日) (読)
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| 3. | (英) Case-Control Studies (日) (読)
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| 4. | (英) Female (日) (読)
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| 5. | (英) Genetic Predisposition to Disease (日) (読)
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| 6. | (英) Genetics, Population (日) (読)
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| 7. | (英) Genome-Wide Association Study (日) (読)
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| 8. | (英) Genotype (日) (読)
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| 9. | (英) Humans (日) (読)
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| 10. | (英) Japan (日) (読)
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| 11. | (英) Male (日) (読)
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| 12. | (英) Middle Aged (日) (読)
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| 13. | (英) Parkinson Disease (日) (読)
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| 14. | (英) Polymorphism, Single Nucleotide (日) (読)
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| 15. | (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読)
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| 16. | (英) Ubiquitin Thiolesterase (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Parkinsonism & Related Disorders (Association of Parkinsonism and Related Disorders)
(pISSN: 1353-8020, eISSN: 1873-5126)
| ○ISSN (任意): | □ | 1873-5126
ISSN: 1353-8020
(pISSN: 1353-8020, eISSN: 1873-5126) Title: Parkinsonism & related disordersTitle(ISO): Parkinsonism Relat DisordPublisher: Elsevier Ltd (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 17
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 473 475
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2011年 2月 22日 (平成 23年 2月 22日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.parkreldis.2011.01.019 (→Scopusで検索)
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| ○PMID (任意): | □ | 21345711 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington, USA. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 5. | (英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, Non-P.H.S. (日)
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| 6. | (英) OtherID: NIHMS276782 (日)
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| 7. | (英) OtherID: PMC3119730 (日)
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