| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): | 1. | 徳島大学.医学研究科.医学専攻 (2004年4月1日〜)
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| ○著者 (必須): | 1. | (英) Okita S (日) 大北 真哉 (読) オオキタ シンヤ
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 2. | 森垣 龍馬 ([徳島大学.大学院医歯薬学研究部.医学域.共同研究講座.先端脳機能研究開発]/[徳島大学.病院.診療科.脳·神経·精神科.脳神経外科])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
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| 3. | (英) Koizumi H (日) (読)
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| ○貢献度 (任意): |
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| 4. | 梶 龍兒 ([徳島大学.研究支援・産官学連携センター])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 5. | 永廣 信治
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 6. | 後藤 惠
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Cell type-specific localization of optineurin in the striatal neurons of mice: Implications for neuronal vulnerability in huntington's disease (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Striatal neuropathology of Huntington's disease (HD) involves primary and progressive degeneration of the medium-sized projection neurons, with relative sparing of the local circuit interneurons. The mechanism for such a patterned cell loss in the HD striatum continues to remain unclear. Optineurin (OPTN) is one of the proteins interacting with huntingtin and plays a protective role in several neurodegenerative disorders. To determine the cellular localization pattern of OPTN in the mouse striatum, we employed a highly sensitive immunohistochemistry with the tyramide signal amplification system. In this study, we show that OPTN appeared as a cytoplasmic protein within the subsets of the striatal neurons. Of particular interest was that OPTN was abundantly expressed in the interneurons, whereas low levels of OPTN were observed in the medium projection neurons. This cell type-specific distribution of OPTN in the striatum is strikingly complementary to the pattern of neuronal loss typically observed in the striatum of patients with HD. We suggest that OPTN abundance is an important cellular factor in considering the cell type-specific vulnerability of striatal neurons in HD. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Blotting, Western (日) (読)
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| 3. | 細胞死 (cell death)
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| 4. | (英) Corpus Striatum (日) (読)
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| 5. | (英) Densitometry (日) (読)
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| 6. | (英) Eye Proteins (日) (読)
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| 7. | (英) Glutamic Acid (日) (読)
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| 8. | (英) Huntington Disease (日) (読)
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| 9. | (英) Image Processing, Computer-Assisted (日) (読)
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| 10. | 免疫組織化学 (immunohistochemistry)
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| 11. | (英) Interneurons (日) (読)
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| 12. | (英) Male (日) (読)
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| 13. | (英) Mice (日) (読)
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| 14. | (英) Mice, Inbred C57BL (日) (読)
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| 15. | (英) Mice, Transgenic (日) (読)
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| 16. | (英) Mutation (日) (読)
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| 17. | (英) Neurons (日) (読)
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| 18. | (英) Serotonin Plasma Membrane Transport Proteins (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Neuroscience ([International Brain Research Organization])
(pISSN: 0306-4522, eISSN: 1873-7544)
| ○ISSN (任意): | □ | 1873-7544
ISSN: 0306-4522
(pISSN: 0306-4522, eISSN: 1873-7544) Title: NeuroscienceTitle(ISO): NeurosciencePublisher: Elsevier Ltd (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 202
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| ○号 (必須): | □ | 27
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| ○頁 (必須): | □ | 363 370
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2012年 1月 初日 (平成 24年 1月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.neuroscience.2011.11.059 (→Scopusで検索)
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| ○PMID (任意): | □ | 22155493 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000299908000035
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.neuroscience.2011.11.059 (日)
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| 2. | (英) Article.Affiliation: Parkinson's Disease and Dystonia Research Center, Tokushima University Hospital, University of Tokushima, Tokushima 770-8503, Japan. (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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