『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=256545EID:256545, Map:0, LastModified:2013年11月8日(金) 09:35:05, Operator:[永廣 信治], Avail:TRUE, Censor:0, Owner:[永廣 信治], Read:継承, Write:継承, Delete:継承.
○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨):
○カテゴリ (推奨): □研究 [継承]
○共著種別 (推奨):
○学究種別 (推奨): □博士課程学生による研究報告 [継承]
○組織 (推奨): 1.徳島大学.医学研究科.医学専攻 (2004年4月1日〜) [継承]
○著者 (必須): 1.木内 智也
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2. (英) Kitazato T. Keiko (日) 北里 慶子 (読) キタザトケイコ
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3.島田 健司 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.脳·神経·精神科.脳神経外科])
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4.八木 謙次
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5.多田 恵曜 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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6.松下 展久
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7.住吉 学
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8.里見 淳一郎
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9.影治 照喜
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10.永廣 信治
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○題名 (必須): □(英) Activation of signal transducer and activator of transcription-3 by a peroxisome proliferator-activated receptor gamma agonist contributes to neuroprotection in the peri-infarct region after ischemia in oophorectomized rats  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) The role of the phosphorylated signal transducer and activator of transcription-3 (p-STAT3) after cerebral ischemia by the peroxisome proliferator-activated receptor (PPAR) agonist pioglitazone (PGZ) remains controversial. Whether the increase in p-STAT3 by estrogen is mediated by the estrogen receptor is also obscure. We examined the role of p-STAT3, PPAR, and estrogen receptor against ischemic brain damage after PGZ treatment. Female Wistar rats subjected or not subjected to bilateral oophorectomy were injected with 1.0 or 2.5 mg/kg PGZ 2 days, 1 day, and 1 hour before 90-minute middle cerebral artery occlusion-reperfusion and compared with vehicle-control rats. The cortical infarct size was larger in ovariectomized than in nonovarietomized rats; it was reduced by PGZ treatment. Inversely with the reduction of the infarct size, PPAR, and p-STAT3 but not estrogen receptor in the peri-infarct area were increased in PGZ-treated compared with vehicle-control rats. The increase in PPAR and p-STAT3 was associated with the transactivation of antiapoptotic and survival genes and the reduction of caspase-3 in this area. Inhibitors of PPAR or STAT3 abolished the PGZ-induced neuroprotection and the increase in p-STAT3. More importantly, p-STAT3 increased by PGZ was bound to PPAR and the complex translocated to the nucleus to dock to the response element through p-STAT3. Our findings suggest that the activation in the peri-infarct region of p-STAT3 and PPAR by PGZ is essential for neuroprotection after ischemia and that PGZ may be of benefit even in postmenopausal stroke patients.  (日)    [継承]
○キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Apoptosis (日) (読) [継承]
3. (英) Basal Ganglia (日) (読) [継承]
4. (英) Brain (日) (読) [継承]
5. (英) Brain Ischemia (日) (読) [継承]
6. (英) Caspase 3 (日) (読) [継承]
7. (英) Cell Nucleus (日) (読) [継承]
8. (英) Cerebral Infarction (日) (読) [継承]
9. (英) DNA (日) (読) [継承]
10. (英) Estrogen Receptor alpha (日) (読) [継承]
11. (英) Female (日) (読) [継承]
12. (英) Neuroprotective Agents (日) (読) [継承]
13. (英) Ovariectomy (日) (読) [継承]
14. (英) PPAR gamma (日) (読) [継承]
15. (英) Protein Transport (日) (読) [継承]
16. (英) Rats (日) (読) [継承]
17. (英) Rats, Wistar (日) (読) [継承]
18. (英) Response Elements (日) (読) [継承]
19. (英) STAT3 Transcription Factor (日) (読) [継承]
20. (英) Thiazolidinediones (日) (読) [継承]
21. (英) Transcriptional Activation (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □Stroke ([American Heart Association])
(pISSN: 0039-2499, eISSN: 1524-4628)

○ISSN (任意): □1524-4628
ISSN: 0039-2499 (pISSN: 0039-2499, eISSN: 1524-4628)
Title: Stroke
Title(ISO): Stroke
Publisher: American Heart Association
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □43 [継承]
○号 (必須): □2 [継承]
○頁 (必須): □478 483 [継承]
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○年月日 (必須): □西暦 2012年 11月 10日 (平成 24年 11月 10日) [継承]
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○DOI (任意): □10.1161/STROKEAHA.111.618926    (→Scopusで検索) [継承]
○PMID (任意): □22076002    (→Scopusで検索) [継承]
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○WOS (任意): □000299798300035 [継承]
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○備考 (任意): 1.(英) Article.ELocationID: 10.1161/STROKEAHA.111.618926  (日)    [継承]
2.(英) Article.Affiliation: Department of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8503, Japan. k-tomoya@xg8.so-net.ne.jp  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tomoya Kinouchi, Keiko T. Kitazato, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Nobuhisa Matsushita, Manabu Sumiyoshi, Junichiro Satomi, Teruyoshi Kageji and Shinji Nagahiro : Activation of signal transducer and activator of transcription-3 by a peroxisome proliferator-activated receptor gamma agonist contributes to neuroprotection in the peri-infarct region after ischemia in oophorectomized rats, Stroke, Vol.43, No.2, 478-483, 2012.
欧文冊子 ● Tomoya Kinouchi, Keiko T. Kitazato, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Nobuhisa Matsushita, Manabu Sumiyoshi, Junichiro Satomi, Teruyoshi Kageji and Shinji Nagahiro : Activation of signal transducer and activator of transcription-3 by a peroxisome proliferator-activated receptor gamma agonist contributes to neuroprotection in the peri-infarct region after ischemia in oophorectomized rats, Stroke, Vol.43, No.2, 478-483, 2012.

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