| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): | 1. | 徳島大学.医学研究科.医学専攻 (2004年4月1日〜)
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| ○著者 (必須): | 1. | 松下 展久
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
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| 2. | (英) Kitazato T. Keiko (日) 北里 慶子 (読) キタザト ケイコ
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| 3. | 多田 恵曜 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| 4. | 住吉 学
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 5. | 島田 健司 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.脳·神経·精神科.脳神経外科])
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| ○学籍番号 (推奨): |
| [継承] |
| 6. | 八木 謙次
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| ○学籍番号 (推奨): |
| [継承] |
| 7. | 兼松 康久
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | 里見 淳一郎
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| ○学籍番号 (推奨): |
| [継承] |
| 9. | 永廣 信治
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Increase in body Na+-to-water ratio is associated with cerebral aneurysm formation in oophorectomized rats (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The incidence of cerebral aneurysms is higher in women than in men, especially postmenopause. Although hypertension is thought to be associated with a high incidence of stroke, not all patients with unruptured cerebral aneurysms are hypertensive. The possibility of water-free Na(+) storage associated with hypertension has been raised. However, whether the increase in the body Na(+)/water ratio that characterizes water-free Na(+) accumulation is associated with the formation of cerebral aneurysms remains obscure. To examine this relationship, Sprague-Dawley female rats subjected to carotid artery ligation were divided into 3 groups: a high-salt diet group (HSD) without and another with bilateral oophorectomy (HSD/OVX) and a third group that underwent additional renal artery ligation (HSD/OVX/RL). Compared with rats receiving a normal diet (shams), water retention was increased in HSD rats but not in HSD/OVX rats. Interestingly, compared with HSD rats, the incidence of cerebral aneurysms and the body Na(+)/water ratio were significantly higher in HSD/OVX and HSD/OVX/RL rats, independent of hypertension. In their aneurysmal wall, ATP12, a subtype of Na(+)/K(+)-ATPase, was downregulated, whereas inflammatory-related molecules were upregulated. Treatment with low-dose olmesartan that did not affect the blood pressure in hypertensive HSD/OVX/RL rats reduced the rate of cerebral aneurysm formation, body Na(+) retention, and the Na(+)/water ratio and upregulated ATP12. These results suggest that the increase in the Na(+)/water ratio and a reduction in ATP12 may be associated with cerebral aneurysm formation. We provide the new insight that the management of water-free Na(+) is important to prevent their development. (日)
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| ○キーワード (推奨): | 1. | (英) Angiotensin II Type 1 Receptor Blockers (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Blood Pressure (日) (読)
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| 4. | (英) Blotting, Western (日) (読)
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| 5. | (英) Body Water (日) (読)
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| 6. | (英) Carotid Arteries (日) (読)
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| 7. | (英) Female (日) (読)
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| 8. | (英) Humans (日) (読)
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| 9. | (英) Hypertension (日) (読)
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| 10. | (英) Imidazoles (日) (読)
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| 11. | (英) Intracranial Aneurysm (日) (読)
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| 12. | (英) Ligation (日) (読)
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| 13. | (英) Ovariectomy (日) (読)
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| 14. | (英) Rats (日) (読)
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| 15. | (英) Rats, Sprague-Dawley (日) (読)
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| 16. | (英) Renal Artery (日) (読)
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| 17. | (英) Sodium (日) (読)
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| 18. | (英) Sodium Chloride, Dietary (日) (読)
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| 19. | (英) Sodium-Potassium-Exchanging ATPase (日) (読)
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| 20. | (英) Tetrazoles (日) (読)
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| 21. | (英) Up-Regulation (日) (読)
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| 22. | (英) Water-Electrolyte Balance (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Hypertension ([American Heart Association])
(pISSN: 0194-911X, eISSN: 1524-4563)
| ○ISSN (任意): | □ | 1524-4563
ISSN: 0194-911X
(pISSN: 0194-911X, eISSN: 1524-4563) Title: Hypertension (Dallas, Tex. : 1979)Title(ISO): HypertensionPublisher: American Heart Association (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 60
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 1309 1315
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2012年 10月 8日 (平成 24年 10月 8日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1161/HYPERTENSIONAHA.112.198762 (→Scopusで検索)
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| ○PMID (任意): | □ | 23045463 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1161/HYPERTENSIONAHA.112.198762 (日)
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| 2. | (英) Article.Affiliation: Department of Neurosurgery, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770-8503, Japan. nobuhisama@gmail.com (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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