『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=256092EID:256092, Map:0, LastModified:2012年9月7日(金) 16:40:01, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[三戸 太郎], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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組織 (推奨):
著者 (必須): 1. (英) Dabour Noha (日) (読)
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[継承]
2. (英) Bando Tetsuya (日) (読)
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[継承]
3. (英) Nakamura Taro (日) (読)
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[継承]
4.宮脇 克行 ([徳島大学.バイオイノベーション研究所]/[徳島大学.生物資源産業学部.生物資源産業学科.生物生産システム講座])
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5.三戸 太郎 ([徳島大学.バイオイノベーション研究所]/[徳島大学.生物資源産業学部.生物資源産業学科.生物生産システム講座])
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6. (英) Ohuchi Hideyo (日) (読)
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7.野地 澄晴 ([徳島大学])
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[継承]
題名 (必須): (英) Cricket body size is altered by systemic RNAi against insulin signaling components and epidermal growth factor receptor.  (日)    [継承]
副題 (任意):
要約 (任意): (英) A long-standing problem of developmental biology is how body size is determined. In Drosophila melanogaster, the insulin/insulin-like growth factor (I/IGF) and target of rapamycin (TOR) signaling pathways play important roles in this process. However, the detailed mechanisms by which insect body growth is regulated are not known. Therefore, we have attempted to utilize systemic nymphal RNA interference (nyRNAi) to knockdown expression of insulin signaling components including Insulin receptor (InR), Insulin receptor substrate (chico), Phosphatase and tensin homologue (Pten), Target of rapamycin (Tor), RPS6-p70-protein kinase (S6k), Forkhead box O (FoxO) and Epidermal growth factor receptor (Egfr) and observed the effects on body size in the Gryllus bimaculatus cricket. We found that crickets treated with double-stranded RNA (dsRNA) against Gryllus InR, chico, Tor, S6k and Egfr displayed smaller body sizes, while Gryllus FoxO nyRNAi-ed crickets exhibited larger than normal body sizes. Furthermore, RNAi against Gryllus chico and Tor displayed slow growth and RNAi against Gryllus chico displayed longer lifespan than control crickets. Since no significant difference in ability of food uptake was observed between the Gryllus chico(nyRNAi) nymphs and controls, we conclude that the adult cricket body size can be altered by knockdown of expressions of Gryllus InR, chico, Tor, S6k, FoxO and Egfr by systemic RNAi. Our results suggest that the cricket is a promising model to study mechanisms underlying controls of body size and life span with RNAi methods.  (日)    [継承]
キーワード (推奨): 1. (英) Amino Acid Sequence (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Body Size (日) (読) [継承]
4. (英) Cloning, Molecular (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Forkhead Transcription Factors (日) (読) [継承]
7. (英) Gene Expression Regulation, Developmental (日) (読) [継承]
8. (英) Genes, Insect (日) (読) [継承]
9. (英) Gryllidae (日) (読) [継承]
10. (英) Insect Proteins (日) (読) [継承]
11. (英) Insulin (日) (読) [継承]
12. (英) Longevity (日) (読) [継承]
13. (英) Male (日) (読) [継承]
14. (英) Molecular Sequence Data (日) (読) [継承]
15. (英) Nymph (日) (読) [継承]
16. (英) RNA Interference (日) (読) [継承]
17. (英) Receptor, Epidermal Growth Factor (日) (読) [継承]
18. (英) Receptor, Insulin (日) (読) [継承]
19. (英) Signal Transduction (日) (読) [継承]
20. (英) TOR Serine-Threonine Kinases (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Development Growth & Differentiation ([日本発生生物学会])
(pISSN: 0012-1592, eISSN: 1440-169X)

ISSN (任意): 1440-169X
ISSN: 0012-1592 (pISSN: 0012-1592, eISSN: 1440-169X)
Title: Development, growth & differentiation
Title(ISO): Dev Growth Differ
Supplier: Japanese Society of Developmental Biologists
Publisher: Wiley Publishing
 (NLM Catalog  (医中誌Web  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 857 869 [継承]
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年月日 (必須): 西暦 2011年 7月 21日 (平成 23年 7月 21日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1440-169X.2011.01291.x    (→Scopusで検索) [継承]
PMID (任意): 21777227    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Life Systems, Institute of Technology and Science, The University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Noha Dabour, Tetsuya Bando, Taro Nakamura, Katsuyuki Miyawaki, Taro Mito, Hideyo Ohuchi and Sumihare Noji : Cricket body size is altered by systemic RNAi against insulin signaling components and epidermal growth factor receptor., Development Growth & Differentiation, Vol.53, No.7, 857-869, 2011.
欧文冊子 ● Noha Dabour, Tetsuya Bando, Taro Nakamura, Katsuyuki Miyawaki, Taro Mito, Hideyo Ohuchi and Sumihare Noji : Cricket body size is altered by systemic RNAi against insulin signaling components and epidermal growth factor receptor., Development Growth & Differentiation, Vol.53, No.7, 857-869, 2011.

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