『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Minato Takuya (日) (読)
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[継承]
2.山本 洋太
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[継承]
3.清家 純一
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[継承]
4.吉田 卓弘 ([徳島大学.病院.診療科.外科.食道・乳腺甲状腺外科])
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[継承]
5. (英) Yamai Hiromichi (日) (読)
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6.武知 浩和
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7. (英) Yuasa Yasuhiro (日) (読)
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8.古北 由仁
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9.後藤 正和 ([徳島大学.大学院医歯薬学研究部.医学域.先端臨床医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学])
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10.坂東 良美 ([徳島大学.病院.中央診療施設等.病理部])
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11.丹黒 章 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Aldehyde Dehydrogenase 1 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Aldehyde dehydrogenase 1 (ALDH1) and CD44 act as important biomarkers in several solid tumors. However, few studies have examined the relationships between ALDH1 expression and the prognosis and clinical characteristics of esophageal squamous cell carcinoma (ESCC). This study was a retrospective case-control study and included 152 patients with ESCC. A total of 56 patients underwent surgery (OP group), 40 patients received neoadjuvant chemotherapy involving weekly docetaxel plus 5-fluorouracil and low-dose cisplatin (DFP therapy) prior to undergoing surgery (NAC group), and 56 patients received initial systemic DFP therapy (CT group). The ALDH1 and CD44 immunohistochemical expression levels of each tumor were evaluated and compared with the prognosis and clinical characteristics of the ESCC patients. In the OP and NAC groups, multivariate analysis found that ALDH1 was independently associated with postoperative recurrence and prognosis (OP group, P=0.004 and 0.016, respectively; NAC group, P=0.026 and 0.014, respectively). In addition, CD44 was found to be associated with postoperative recurrence in the OP group and prognosis in the NAC group (P=0.024 and 0.047, respectively). Among the ALDH1-negative clinical stage II/III patients, the OP and NAC groups displayed better prognoses than the CT group (P<0.001). However, among the ALDH1-positive clinical stage II/III patients, the OP and NAC groups displayed poorer prognoses than the CT group (P=0.049). ALDH1 was found to be a predictor of postoperative recurrence and prognosis in ESCC, and CD44 might be a predictor of recurrence and prognosis. ALDH1 expression might affect the treatment strategy for ESCC.  (日) BACKGROUND: Aldehyde dehydrogenase 1 (ALDH1) and CD44 act as important biomarkers in several solid tumors. However, few studies have examined the relationships between ALDH1 expression and the prognosis and clinical characteristics of esophageal squamous cell carcinoma (ESCC). METHODS: This study was a retrospective case-control study and included 152 patients with ESCC. A total of 56 patients underwent surgery (OP group), 40 patients received neoadjuvant chemotherapy involving weekly docetaxel plus 5-fluorouracil and low-dose cisplatin (DFP therapy) prior to undergoing surgery (NAC group), and 56 patients received initial systemic DFP therapy (CT group). The ALDH1 and CD44 immunohistochemical expression levels of each tumor were evaluated and compared with the prognosis and clinical characteristics of the ESCC patients. RESULTS: In the OP and NAC groups, multivariate analysis found that ALDH1 was independently associated with postoperative recurrence and prognosis (OP group, P = 0.004 and 0.016, respectively; NAC group, P = 0.026 and 0.014, respectively). In addition, CD44 was found to be associated with postoperative recurrence in the OP group and prognosis in the NAC group (P = 0.024 and 0.047, respectively). Among the ALDH1-negative clinical stage II/III patients, the OP and NAC groups displayed better prognoses than the CT group (P < 0.001). However, among the ALDH1-positive clinical stage II/III patients, the OP and NAC groups displayed poorer prognoses than the CT group (P = 0.049). CONCLUSIONS: ALDH1 was found to be a predictor of postoperative recurrence and prognosis in ESCC, and CD44 might be a predictor of recurrence and prognosis. ALDH1 expression might affect the treatment strategy for ESCC.   [継承]
キーワード (推奨): 1. (英) Aged (日) (読) [継承]
2. (英) Antigens, CD44 (日) (読) [継承]
3. (英) Antineoplastic Combined Chemotherapy Protocols (日) (読) [継承]
4. (英) Carcinoma, Squamous Cell (日) (読) [継承]
5. (英) Case-Control Studies (日) (読) [継承]
6. (英) Chi-Square Distribution (日) (読) [継承]
7. (英) Cisplatin (日) (読) [継承]
8. (英) Disease-Free Survival (日) (読) [継承]
9. (英) Esophageal Neoplasms (日) (読) [継承]
10. (英) Esophagectomy (日) (読) [継承]
11. (英) Female (日) (読) [継承]
12. (英) Fluorouracil (日) (読) [継承]
13. (英) Humans (日) (読) [継承]
14. (英) Isoenzymes (日) (読) [継承]
15. (英) Kaplan-Meier Estimate (日) (読) [継承]
16. (英) Male (日) (読) [継承]
17. (英) Middle Aged (日) (読) [継承]
18. (英) Multivariate Analysis (日) (読) [継承]
19. (英) Neoadjuvant Therapy (日) (読) [継承]
20. (英) Neoplasm Recurrence, Local (日) (読) [継承]
21. (英) Proportional Hazards Models (日) (読) [継承]
22. (英) Retinal Dehydrogenase (日) (読) [継承]
23. (英) Retrospective Studies (日) (読) [継承]
24. (英) Taxoids (日) (読) [継承]
25. (英) Tumor Markers, Biological (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Annals of Surgical Oncology (Society of Surgical Oncology (U.S.))
(pISSN: 1068-9265, eISSN: 1534-4681)

ISSN (任意): 1534-4681
ISSN: 1068-9265 (pISSN: 1068-9265, eISSN: 1534-4681)
Title: Annals of surgical oncology
Title(ISO): Ann. Surg. Oncol.
Supplier: Springer Online Journal Archive
Publisher: Springer New York
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年月日 (必須): 西暦 2012年 1月 31日 (平成 24年 1月 31日) [継承]
URL (任意):
DOI (任意): 10.1245/s10434-012-2535-8    (→Scopusで検索) [継承]
PMID (任意): 22847125    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000312709400030 [継承]
Scopus (任意): 2-s2.0-84871802319 [継承]
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備考 (任意): 1.(英) Affiliation: Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan, minatot@zentuuji.hosp.go.jp.  (日)    [継承]
2.(英) PublicationType: JOURNAL ARTICLE  (日)    [継承]

標準的な表示

和文冊子 ● Takuya Minato, Yota Yamamoto, Jun-ichi Seike, Takahiro Yoshida, Hiromichi Yamai, Hirokazu Takechi, Yasuhiro Yuasa, Yoshihito Furukita, Masakazu Goto, Yoshimi Bando and Akira Tangoku : Aldehyde Dehydrogenase 1 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma., Annals of Surgical Oncology, Vol.20, No.1, 209-217, 2012.
欧文冊子 ● Takuya Minato, Yota Yamamoto, Jun-ichi Seike, Takahiro Yoshida, Hiromichi Yamai, Hirokazu Takechi, Yasuhiro Yuasa, Yoshihito Furukita, Masakazu Goto, Yoshimi Bando and Akira Tangoku : Aldehyde Dehydrogenase 1 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma., Annals of Surgical Oncology, Vol.20, No.1, 209-217, 2012.

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