| ○種別 (必須): |
| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Takei Yuichiro (日) (読)
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| 2. | 山本 浩範
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| 3. | (英) Sato Tadatoshi (日) (読)
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| [継承] |
| 4. | (英) Otani Ayako (日) (読)
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| [継承] |
| 5. | (英) Kozai Mina (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Masuda Masashi (日) (読)
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| [継承] |
| 7. | 竹谷 豊 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.臨床食管理学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Muto-Sato Kazusa (日) (読)
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| ○貢献度 (任意): |
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| [継承] |
| 9. | (英) Lanske Beate (日) (読)
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| [継承] |
| 10. | 武田 英二
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Stanniocalcin 2 is associated with ectopic calcification in α-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Ectopic calcification of soft tissues can have severe clinical consequences especially when localized to vital organs such as heart, arteries and kidneys. Mammalian stanniocalcin (STC) 1 and 2 are glycoprotein hormones identified as calcium/phosphate-regulating hormones. The mRNA of STCs is upregulated in the kidney of α-klotho mutant (kl/kl) mice, which have hypercalcemia, hyperphosphatemia and hypervitaminosis D and exhibit a short life span, osteopenia and ectopic calcification. In the present study, we investigated the distribution and localization of STCs in kl/kl mice. Quantitative RT-PCR revealed that renal mRNA expression of STC2 was increased in both kl/kl mice and fibroblast growth factor 23 (Fgf23)-null mice compared with wild type mice. Interestingly, STC2 protein was focally localized with the calcified lesions of renal arterioles, renal tubular cells, heart and aorta in kl/kl mice. In vitro analysis of rat aortic vascular smooth muscle (A-10) cells showed that inorganic phosphate (Pi) stimulation significantly increased STC2 mRNA levels as well as that of osteocalcin, osteopontin and the type III sodium-dependent phosphate co-transporter (PiT-1), and induced STC2 secretion. Interestingly, the knockdown with a small interfering RNA or the over-expression of STC2 showed acceleration and inhibition of Pi-induced calcification in A-10 cells, respectively. These results suggest that the up-regulation of STC2 gene expression resulting from abnormal α-klotho-Fgf23 signaling may contribute to limitation of ectopic calcification and thus STC2 represents a novel target gene for cardio-renal syndrome. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Aorta (日) (読)
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| 3. | (英) Calcinosis (日) (読)
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| 4. | (英) Fibroblast Growth Factors (日) (読)
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| 5. | (英) Gene Expression Profiling (日) (読)
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| 6. | (英) Gene Expression Regulation (日) (読)
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| 7. | (英) Glycoproteins (日) (読)
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| 8. | (英) Humans (日) (読)
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| 9. | 高リン血症 (hyperphosphatemia)
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| 10. | (英) In Situ Hybridization (日) (読)
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| 11. | (英) Kidney (日) (読)
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| 12. | (英) Mice (日) (読)
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| 13. | (英) Mice, Mutant Strains (日) (読)
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| 14. | (英) Muscle, Smooth, Vascular (日) (読)
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| 15. | 心筋 (myocardium)
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| 16. | (英) Myocytes, Smooth Muscle (日) (読)
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| 17. | (英) Organ Specificity (日) (読)
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| 18. | (英) Phosphates (日) (読)
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| 19. | (英) Protein Transport (日) (読)
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| 20. | (英) RNA, Messenger (日) (読)
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| 21. | (英) Rats (日) (読)
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| 22. | (英) Receptors, Cell Surface (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Bone (International Bone and Mineral Society)
(pISSN: 8756-3282, eISSN: 1873-2763)
| ○ISSN (任意): | □ | 1873-2763
ISSN: 8756-3282
(pISSN: 8756-3282, eISSN: 1873-2763) Title: BoneTitle(ISO): BonePublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 50
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 998 1005
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2012年 1月 21日 (平成 24年 1月 21日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bone.2012.01.006 (→Scopusで検索)
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| ○PMID (任意): | □ | 22285620 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto-cho 3, Tokushima 770-8503, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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