『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=253215EID:253215, Map:0, LastModified:2013年8月23日(金) 09:31:09, Operator:[吉田 賀弥], Avail:TRUE, Censor:0, Owner:[吉田 賀弥], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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著者 (必須): 1.吉田 賀弥 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健教育学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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2.岡村 裕彦
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3.落合 和彦
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4.星野 由美
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5.羽地 達次
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6.吉岡 昌美
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7.日野出 大輔 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健衛生学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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8.吉田 秀夫
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題名 (必須): (英) PKR plays a positive role in osteoblast differentiation by regulating GSK-3b activity through a b-catenin-independent pathway  (日)    [継承]
副題 (任意):
要約 (任意): (英) Double-stranded RNA-dependent protein kinase (PKR) is involved in various cellular functions. We previously reported that PKR regulates osteoblast differentiation, but the specific mechanisms by which this occurs remain unclear. In this study, we investigated the role of PKR in Glycogen synthase kinase 3 (GSK-3) regulation of osteoblast differentiation. Lithium chloride (LiCl), a GSK-3 inhibitor, increased GSK-3 phosphorylation in MC3T3-E1 and MG-63 cells. LiCl also inhibited Runx2 and expression of its regulated genes, causing inhibition of Alkaline phosphatase activity and mineralization. LiCl injection to the calvaria in mice suppressed bone formation. Further, GSK-3 phosphorylation was increased in osteoblasts, by Akt-independent mechanisms, in which PKR was constitutively inactivated. A PKR inhibitor, 2-aminopurine, also induced GSK-3 phosphorylation in MC3T3-E1 and MG-63 cells. Further, Runx2 and its regulated genes were inhibited in PKR-inactivated osteoblasts, and differentiation was suppressed through a -catenin-independent pathway. PKR positively regulates the differentiation of osteoblasts by mediating GSK-3 activity through a -catenin-independent pathway.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cell Differentiation (日) (読) [継承]
3. (英) Cell Line (日) (読) [継承]
4. (英) Enzyme Activation (日) (読) [継承]
5. (英) Glycogen Synthase Kinase 3 (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Lithium Chloride (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Models, Biological (日) (読) [継承]
10. (英) Osteoblasts (日) (読) [継承]
11. (英) Osteogenesis (日) (読) [継承]
12. (英) Phosphorylation (日) (読) [継承]
13. (英) Proto-Oncogene Proteins c-akt (日) (読) [継承]
14. (英) Signal Transduction (日) (読) [継承]
15. (英) Skull (日) (読) [継承]
16. (英) beta Catenin (日) (読) [継承]
17. (英) eIF-2 Kinase (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Molecular and Cellular Endocrinology ([Elsevier])
(pISSN: 0303-7207, eISSN: 1872-8057)

ISSN (任意): 1872-8057
ISSN: 0303-7207 (pISSN: 0303-7207, eISSN: 1872-8057)
Title: Molecular and cellular endocrinology
Title(ISO): Mol. Cell. Endocrinol.
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 361 [継承]
(必須): 1-2 [継承]
(必須): 99 105 [継承]
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年月日 (必須): 西暦 2012年 9月 25日 (平成 24年 9月 25日) [継承]
URL (任意):
DOI (任意): 10.1016/j.mce.2012.03.019    (→Scopusで検索) [継承]
PMID (任意): 22484461    (→Scopusで検索) [継承]
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WOS (任意): 000307692200010 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.mce.2012.03.019  (日)    [継承]
2.(英) Article.Affiliation: Department of Fundamental Oral Health Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima, Japan. kaya@dent.tokushima-u.ac.jp  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kaya Yoshida, Hirohiko Okamura, Kazuhiko Ochiai, Yumi Hoshimo, Tatsuji Haneji, Masami Yoshioka, Daisuke Hinode and Hideo Yoshida : PKR plays a positive role in osteoblast differentiation by regulating GSK-3b activity through a b-catenin-independent pathway, Molecular and Cellular Endocrinology, Vol.361, No.1-2, 99-105, 2012.
欧文冊子 ● Kaya Yoshida, Hirohiko Okamura, Kazuhiko Ochiai, Yumi Hoshimo, Tatsuji Haneji, Masami Yoshioka, Daisuke Hinode and Hideo Yoshida : PKR plays a positive role in osteoblast differentiation by regulating GSK-3b activity through a b-catenin-independent pathway, Molecular and Cellular Endocrinology, Vol.361, No.1-2, 99-105, 2012.

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