『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=253056EID:253056, Map:0, LastModified:2018年5月14日(月) 16:18:37, Operator:[有持 秀喜], Avail:TRUE, Censor:0, Owner:[安友 康二], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Lian Gaojian (日) 練 髙建 (読) りあん がおしん
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貢献度 (任意):
学籍番号 (推奨): **** [ユーザ]
[継承]
2.有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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3.北村 明子
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学籍番号 (推奨):
[継承]
4.西田 純
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学籍番号 (推奨):
[継承]
5. (英) Li Shigen (日) (読)
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学籍番号 (推奨):
[継承]
6.岸原 健二
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学籍番号 (推奨):
[継承]
7.前川 洋一
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[継承]
8.安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The interplay of CD4(+) and CD8(+) T cells targeting autoantigens is responsible for the progression of a number of autoimmune diseases, including type 1 diabetes mellitus (T1D). Understanding the molecular mechanisms that regulate T cell activation is crucial for designing effective therapies for autoimmune diseases. We probed a panel of Abs with T cell-modulating activity and identified a mAb specific for the H chain of CD98 (CD98hc) that was able to suppress T cell proliferation. The anti-CD98hc mAb also inhibited Ag-specific proliferation and the acquisition of effector function by CD4(+) and CD8(+) T cells in vitro and in vivo. Injection of the anti-CD98hc mAb completely prevented the onset of cyclophosphamide-induced diabetes in NOD mice. Treatment of diabetic NOD mice with anti-CD98hc reversed the diabetic state to normal levels, coincident with decreased proliferation of CD4(+) T cells. Furthermore, treatment of diabetic NOD mice with CD98hc small interfering RNA resolved T1D. These data indicate that strategies targeting CD98hc might have clinical application for treating T1D and other T cell-mediated autoimmune diseases.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antibodies, Monoclonal (日) (読) [継承]
3. (英) Antigens, CD98 Heavy Chain (日) (読) [継承]
4. (英) CD4-Positive T-Lymphocytes (日) (読) [継承]
5. (英) CD8-Positive T-Lymphocytes (日) (読) [継承]
6. (英) Cyclophosphamide (日) (読) [継承]
7. (英) Diabetes Mellitus, Type 1 (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Growth Inhibitors (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Mice, Inbred BALB C (日) (読) [継承]
12. (英) Mice, Inbred C57BL (日) (読) [継承]
13. (英) Mice, Inbred NOD (日) (読) [継承]
14. (英) Mice, SCID (日) (読) [継承]
15. (英) Mice, Transgenic (日) (読) [継承]
16. (英) Rats (日) (読) [継承]
17. (英) Rats, Wistar (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2012年 1月 30日 (平成 24年 1月 30日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.1102586    (→Scopusで検索) [継承]
PMID (任意): 22291182    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Immunology and Parasitology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Gaojian Lian, Hideki Arimochi, Akiko Kitamura, Jun Nishida, Shigen Li, Kenji Kishihara, Yoichi Maekawa and Koji Yasutomo : Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice., The Journal of Immunology, Vol.188, No.5, 2227-2234, 2012.
欧文冊子 ● Gaojian Lian, Hideki Arimochi, Akiko Kitamura, Jun Nishida, Shigen Li, Kenji Kishihara, Yoichi Maekawa and Koji Yasutomo : Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice., The Journal of Immunology, Vol.188, No.5, 2227-2234, 2012.

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