| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kuwahara Tomomi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Ogura Yositoshi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Oshima Kenshiro (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Kurokawa Ken (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Ooka Tadasuke (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Hirakawa Hideki (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Itoh Takehiko (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Nakayama-Imaohji Haruyuki (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 9. | (英) Ichimura Minoru (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 10. | (英) Itoh Kikuji (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 11. | 石舟 智恵子 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 12. | 前川 洋一
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 13. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 14. | (英) Hattori Masahira (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 15. | (英) Hayashi Tetsuya (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) The lifestyle of the segmented filamentous bacterium: a non-culturable gut-associated immunostimulating microbe inferred by whole-genome sequencing. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Numerous microbes inhabit the mammalian intestinal track and strongly impact host physiology; however, our understanding of this ecosystem remains limited owing to the high complexity of the microbial community and the presence of numerous non-culturable microbes. Segmented filamentous bacteria (SFBs), which are clostridia-related Gram-positive bacteria, are among such non-culturable populations and are well known for their unique morphology and tight attachment to intestinal epithelial cells. Recent studies have revealed that SFBs play crucial roles in the post-natal maturation of gut immune function, especially the induction of Th17 lymphocytes. Here, we report the complete genome sequence of mouse SFBs. The genome, which comprises a single circular chromosome of 1 620 005 bp, lacks genes for the biosynthesis of almost all amino acids, vitamins/cofactors and nucleotides, but contains a full set of genes for sporulation/germination and, unexpectedly, for chemotaxis/flagella-based motility. These findings suggest a triphasic lifestyle of the SFB, which comprises two types of vegetative (swimming and epicellular parasitic) phases and a dormant (spore) phase. Furthermore, SFBs encode four types of flagellin, three of which are recognized by Toll-like receptor 5 and could elicit the innate immune response. Our results reveal the non-culturability, lifestyle and immunostimulation mechanisms of SFBs and provide a genetic basis for the future development of the SFB cultivation and gene-manipulation techniques. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
| [継承] |
| 2. | (英) Bacteria (日) (読)
| [継承] |
| 3. | (英) Biosynthetic Pathways (日) (読)
| [継承] |
| 4. | (英) Chemotaxis (日) (読)
| [継承] |
| 5. | (英) Chromosomes, Bacterial (日) (読)
| [継承] |
| 6. | (英) Flagella (日) (読)
| [継承] |
| 7. | (英) Flagellin (日) (読)
| [継承] |
| 8. | (英) Gene Order (日) (読)
| [継承] |
| 9. | (英) Genome, Bacterial (日) (読)
| [継承] |
| 10. | (英) Humans (日) (読)
| [継承] |
| 11. | (英) Intestines (日) (読)
| [継承] |
| 12. | (英) Male (日) (読)
| [継承] |
| 13. | (英) Mice (日) (読)
| [継承] |
| 14. | (英) Mice, Inbred BALB C (日) (読)
| [継承] |
| 15. | (英) Phylogeny (日) (読)
| [継承] |
| 16. | (英) Sequence Analysis, DNA (日) (読)
| [継承] |
| 17. | (英) Spores (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | DNA Research ([Oxford University Press])
(pISSN: 1340-2838, eISSN: 1756-1663)
| ○ISSN (任意): | □ | 1756-1663
ISSN: 1340-2838
(pISSN: 1340-2838, eISSN: 1756-1663) Title: DNA research : an international journal for rapid publication of reports on genes and genomesTitle(ISO): DNA ResPublisher: Oxford University Press (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 18
| [継承] |
| ○号 (必須): | □ | 4
| [継承] |
| ○頁 (必須): | □ | 291 303
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2011年 7月 26日 (平成 23年 7月 26日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1093/dnares/dsr022 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 21791478 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1093/dnares/dsr022 (日)
| [継承] |
| 2. | (英) Article.Affiliation: Department of Microbiology, Kagawa University, Miki-cho, Kita-gun, Kagawa, Japan. (日)
| [継承] |
| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
| [継承] |
| 5. | (英) OtherID: PMC3158464 (日)
| [継承] |