『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=252840EID:252840, Map:0, LastModified:2018年3月20日(火) 15:37:36, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[遠藤 逸朗], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.松本 俊夫
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2. (英) Kuriwaka-Kido Rika (日) (読)
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3.近藤 剛史
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4.遠藤 逸朗 ([徳島大学.大学院医歯薬学研究部.保健科学域.保健科学部門.医用検査学系.生体機能解析学])
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5.木戸 慎介
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題名 (必須): (英) Regulation of osteoblast differentiation by interleukin-11 via AP-1 and Smad signaling.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Mechanical stress and parathyroid hormone (PTH) are major stimulators, and aging and glucocorticoids excess are important suppressors of osteoblast differentiation. Mechanical stress and PTH stimulate interleukin (IL)-11 expression in cells of osteoblast lineage by enhancing transcription of IL-11 gene via an increase in intracellular Ca² . The elevated Ca² activates extracellular signal-regulated kinase (ERK) to enhance phosphorylation of cyclic AMP response element-binding protein (CREB), which binds to the fosB gene promoter and enhances FosB expression. FosB dimerizes with JunD on the IL-11 gene promoter to enhance its transcription. Both mechanical stress and PTH also stimulate phosphorylation of Smad1 via an activation of protein kinase C (PKC). Phosphorylated Smad1 binds to the IL-11 gene promoter and forms complex with FosB/JunD to further enhance IL-11 gene transcription. The increased IL-11 then suppresses expression of Wnt inhibitors, including Dickkopf 1 (Dkk1) and 2, and enhances Wnt signaling to stimulate osteoblast differentiation and inhibit adipocyte differentiation. The suppression of osteoblast differentiation by aging involves a decrease in IL-11 gene transcription by a reduction in JunD binding to the activator protein (AP)-1 site of the IL-11 gene promoter. Glucocorticoids inhibit transcriptional activation of IL-11 gene by an interaction of glucocorticoid-glucocorticoid receptor (GR) complex with FosB/JunD heterodimer. Thus, factors that enhance osteoblast differentiation stimulate, and those which suppress osteoblast differentiation inhibit IL-11 gene transcription, and IL-11 enhances Wnt signaling by suppressing expression of its inhibitors. These observations are consistent with the notion that IL-11 mediates stimulatory and inhibitory signals of osteoblast differentiation by affecting Wnt signaling.  (日)    [継承]
キーワード (推奨): 1. (英) Adipocytes (日) (読) [継承]
2. (英) Aging (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Cell Differentiation (日) (読) [継承]
5. (英) Gene Expression Regulation, Developmental (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Interleukin-11 (日) (読) [継承]
8. (英) Osteoblasts (日) (読) [継承]
9. (英) Osteogenesis (日) (読) [継承]
10. (英) Signal Transduction (日) (読) [継承]
11. (英) Smad Proteins (日) (読) [継承]
12. (英) Transcription Factor AP-1 (日) (読) [継承]
13. (英) Wnt Signaling Pathway (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrine Journal ([社団法人 日本内分泌学会])
(pISSN: 0918-8959, eISSN: 1348-4540)

ISSN (任意): 1348-4540
ISSN: 0918-8959 (pISSN: 0918-8959, eISSN: 1348-4540)
Title: Endocrine journal
Title(ISO): Endocr. J.
Supplier: 一般社団法人 日本内分泌学会
Publisher: Japan Endocrine Sociey/Nihon Naibunpi Gakkai
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 59 [継承]
(必須): 2 [継承]
(必須): 91 101 [継承]
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年月日 (必須): 西暦 2011年 9月 17日 (平成 23年 9月 17日) [継承]
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DOI (任意): 10.1507/endocrj.EJ11-0219    (→Scopusで検索) [継承]
PMID (任意): 21931225    (→Scopusで検索) [継承]
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WOS (任意): 000301962200001 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences, Tokushima, Japan. toshimat@clin.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]

標準的な表示

和文冊子 ● Toshio Matsumoto, Rika Kuriwaka-Kido, Takeshi Kondo, Itsuro Endo and Shinsuke Kido : Regulation of osteoblast differentiation by interleukin-11 via AP-1 and Smad signaling., Endocrine Journal, Vol.59, No.2, 91-101, 2011.
欧文冊子 ● Toshio Matsumoto, Rika Kuriwaka-Kido, Takeshi Kondo, Itsuro Endo and Shinsuke Kido : Regulation of osteoblast differentiation by interleukin-11 via AP-1 and Smad signaling., Endocrine Journal, Vol.59, No.2, 91-101, 2011.

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