『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=252185)

EID=252185EID:252185, Map:0, LastModified:2014年11月28日(金) 15:14:17, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[江口 覚], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.河野 崇
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[継承]
2.曽我 朋宏 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域医療人材育成(医学域)])
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学籍番号 (推奨):
[継承]
3. (英) Chi Haidong (日) (読)
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[継承]
4.江口 覚 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学]/[徳島大学.病院.診療科.歯科口腔外科.歯科麻酔科])
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[継承]
5. (英) Yamazaki Fumimoto (日) 山崎 史幹 (読) やまざき ふみもと
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学籍番号 (推奨):
[継承]
6. (英) Yokoyama Masataka (日) 横山 正尚 (読) よこやま まさたか
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Role of the neurosteroid allopregnanolone in the hyperalgesic behavior induced by painful nerve injury in rats  (日)    [継承]
副題 (任意):
要約 (任意): (英) The neurosteroid allopregnanolone (AP) influences the excitability of the central nervous system by acting as a positive allosteric modulator of γ-aminobutyric acid type A (GABA(A)) receptors. Here, we investigated the role of AP and its therapeutic potential in rats that showed hyperalgesic behavior after undergoing spinal nerve ligation (SNL). AP levels measured in the spinal cord and brain of rats that underwent SNL were greater than the corresponding levels in control animals. More importantly, spinal AP levels in hyperalgesic rats were lower than those in the rats that did not develop hyperalgesia following SNL; in contrast, brain AP levels were comparable among these groups. No differences in serum AP levels were observed among the groups. In addition, intrathecal exogenous administration of AP showed the antihyperalgesic effects in hyperalgesic rats after SNL. These findings suggest that changes in spinal AP biosynthesis are involved in the pathogenesis of neuropathic pain following peripheral nerve injury, and pharmacological manipulation of this phenomenon may provide a potential therapeutic target for neuropathic pain.  (日)    [継承]
キーワード (推奨): 1. (英) Anesthetics (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (brain) [継承]
4. (英) Hyperalgesia (日) (読) [継承]
5. (英) Neuralgia (日) (読) [継承]
6. (英) Neurotransmitter Agents (日) (読) [継承]
7. (英) Pain (日) (読) [継承]
8. (英) Peripheral Nerve Injuries (日) (読) [継承]
9. (英) Pregnanolone (日) (読) [継承]
10. (英) Rats (日) (読) [継承]
11.脊髄 (spinal cord) [継承]
12. (英) Spinal Nerves (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Anesthesia ([社団法人 日本麻酔科学会])
(pISSN: 0913-8668, eISSN: 1438-8359)

ISSN (任意): 0913-8668
ISSN: 0913-8668 (pISSN: 0913-8668, eISSN: 1438-8359)
Title: Journal of anesthesia
Title(ISO): J Anesth
Supplier: Springer Online Journal Archive
Publisher: Springer Japan
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
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(必須): 25 [継承]
(必須): 6 [継承]
(必須): 942 945 [継承]
都市 (任意):
年月日 (必須): 西暦 2011年 12月 初日 (平成 23年 12月 初日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/10030449157/ [継承]
DOI (任意): 10.1007/s00540-011-1216-2    (→Scopusで検索) [継承]
PMID (任意): 21879341    (→Scopusで検索) [継承]
NAID (任意): 10030449157 [継承]
WOS (任意): 000298047600025 [継承]
Scopus (任意): 2-s2.0-84355161737 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1007/s00540-011-1216-2  (日)    [継承]
2.(英) Article.Affiliation: Department of Anesthesiology and Critical Care Medicine, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan. takashika@kochi-u.ac.jp  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takashi Kawano, Tomohiro Soga, Haidong Chi, Satoru Eguchi, Fumimoto Yamazaki and Masataka Yokoyama : Role of the neurosteroid allopregnanolone in the hyperalgesic behavior induced by painful nerve injury in rats, Journal of Anesthesia, Vol.25, No.6, 942-945, 2011.
欧文冊子 ● Takashi Kawano, Tomohiro Soga, Haidong Chi, Satoru Eguchi, Fumimoto Yamazaki and Masataka Yokoyama : Role of the neurosteroid allopregnanolone in the hyperalgesic behavior induced by painful nerve injury in rats, Journal of Anesthesia, Vol.25, No.6, 942-945, 2011.

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