『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=251817)

EID=251817EID:251817, Map:0, LastModified:2017年12月4日(月) 14:01:09, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[西岡 安彦], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Miyake Keiko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.谷 憲治 ([徳島大学.病院.中央診療施設等.総合診療部]/[徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).総合診療医学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.柿内 聡司
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Suzuka Chiyuki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.豊田 優子
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.岸 潤
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.手塚 敏史
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8.湯浅 志乃
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9.埴淵 昌毅
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
10.青野 純典 ([徳島大学.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.先端医療創生科学講座.呼吸器・膠原病内科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
11.西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
12.曽根 三郎
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Epidermal growth factor receptor-tyrosine kinase inhibitor (gefitinib) augments pneumonitis, but attenuates lung fibrosis in response to radiation injury in rats  (日)    [継承]
副題 (任意):
要約 (任意): (英) Gefitinib, an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has been reported to be associated with interstitial lung disorders, and their high incidence and mortality have become a matter of great concern, especially in Japan. In this study, we investigated the effect of gefitinib on different phases of radiation-induced lung disorders in an experimental model. The thoraxes of Wistar rats were irradiated on day 1 with a single X-ray dose of 20 Gy, and gefitinib (50 mg/kg/day) was orally administered from day 1 to 14. The rat lungs were harvested on days 15 and 57 and the bronchoalveolar lavage (BAL) was performed. Gefitinib treatment increased the infiltration of inflammatory cells, which produced more pro-inflammatory cytokines (IL-6, IL-1), in the lungs of the irradiated rats on days 15 and 57, while gefitinib treatment reduced collagen content of the lungs in irradiated rats and decreased proliferation and EGFR expression in the lung fibroblasts from irradiated rats on day 57. In irradiated rats, gefitinib treatment augmented lung inflammation, including inflammatory cell infiltration and pro-inflammatory cytokine expression, while gefitinib treatment attenuated fibrotic lung remodeling due to the inhibition of lung fibroblast proliferation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Disease Models, Animal (日) (読) [継承]
3. (英) Male (日) (読) [継承]
4. (英) Protein Kinase Inhibitors (日) (読) [継承]
5. (英) Pulmonary Fibrosis (日) (読) [継承]
6. (英) Quinazolines (日) (読) [継承]
7. (英) Radiation Pneumonitis (日) (読) [継承]
8. (英) Rats (日) (読) [継承]
9. (英) Rats, Wistar (日) (読) [継承]
10. (英) Receptor, Epidermal Growth Factor (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 59 [継承]
(必須): 1-2 [継承]
(必須): 174-185 174-185 [継承]
都市 (任意):
年月日 (必須): 西暦 2012年 2月 初日 (平成 24年 2月 初日) [継承]
URL (任意):
DOI (任意): 10.2152/jmi.59.174    (→Scopusで検索) [継承]
PMID (任意): 22450006    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
機関リポジトリ : 106019 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Keiko Miyake, Kenji Tani, Souji Kakiuchi, Chiyuki Suzuka, Yuko Toyoda, Jun Kishi, Toshifumi Tezuka, Shino Yuasa, Masaki Hanibuchi, Yoshinori Aono, Yasuhiko Nishioka and Saburo Sone : Epidermal growth factor receptor-tyrosine kinase inhibitor (gefitinib) augments pneumonitis, but attenuates lung fibrosis in response to radiation injury in rats, The Journal of Medical Investigation : JMI, Vol.59, No.1-2, 174-185, 2012.
欧文冊子 ● Keiko Miyake, Kenji Tani, Souji Kakiuchi, Chiyuki Suzuka, Yuko Toyoda, Jun Kishi, Toshifumi Tezuka, Shino Yuasa, Masaki Hanibuchi, Yoshinori Aono, Yasuhiko Nishioka and Saburo Sone : Epidermal growth factor receptor-tyrosine kinase inhibitor (gefitinib) augments pneumonitis, but attenuates lung fibrosis in response to radiation injury in rats, The Journal of Medical Investigation : JMI, Vol.59, No.1-2, 174-185, 2012.

関連情報

Number of session users = 4, LA = 0.56, Max(EID) = 376398, Max(EOID) = 1008125.