『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須):
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.東島 潤
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.栗田 信浩
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.宮谷 知彦
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.吉川 幸造 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.森本 慎也
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.西岡 将規 (->個人[發知 将規])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.岩田 貴 ([徳島大学.教養教育院])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8.島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Expression of histone deacetylase 1 and metastasis-associated protein 1 as prognostic factors in colon cancer.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Histone deacetylase 1 (HDAC1) and metastasis-associated protein 1 (MTA1) form the nucleosome remodeling and histone deacetylation (NuRD) complex and may possibly play a central role in cancer development. However, limited data has been reported regarding the expression of both HDAC1 and MTA1. The aim of the present study was to clarify the clinical role of HDAC1 and MTA1 expression in colon cancer. Seventy-four patients with colon cancer, who underwent colectomy at our institution, were enrolled in this study. Expression of HDAC1 and MTA1 was examined immunohistochemically. The patients were divided into four groups: HDAC1-positive group (n=58), HDAC1-negative group (n=16), MTA1-positive group (n=38) and MTA1-negative group (n=36). Clinicopathological factors and survival rates were compared between the groups. Regarding the clinicopathological factors, the depth of tumor invasion and stage correlated significantly with HDAC1 expression (p<0.05). Age, depth of tumor invasion and vascular invasion tended to correlate with MTA1 expression. The 5-year survival rate in the HDAC1-positive group (55.1%) was significantly worse compared to the HDAC1-negative group (86.5%) (p<0.05), and the 5-year survival rate of the MTA1-positive group (50.5%) was significantly worse than that of the MTA1-negative group (73.1%) (p=0.05). In patients with stages II-IV and curability A, B, the survival rate in those with HDAC1-positive expression was significantly worse than those with HDAC1-negative expression (p<0.05), and the survival rate of the MTA1-positive group tended to be worse than that of the MTA1-negative group (p=0.07). Overall survival in both the HDAC1 and MTA1-positive groups was significantly worse than overall survival of the other groups (p<0.05). Disease-free survival in both the HDAC1- and MTA1-positive groups, among patients with stages II-IV and curability A, B, was also significantly worse than that of the other groups (p<0.05). HDAC1 and MTA1 expression levels were significantly related to poorer prognosis. Therefore, HDAC1 and MTA1 expression levels are potential prognostic indicators for colon cancer.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) Aged, 80 and over (日) (読) [継承]
4. (英) Colonic Neoplasms (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Histone Deacetylase 1 (日) (読) [継承]
7. (英) Histone Deacetylases (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9.免疫組織化学 (immunohistochemistry) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Middle Aged (日) (読) [継承]
12. (英) Neoplasm Metastasis (日) (読) [継承]
13. (英) Neoplasm Staging (日) (読) [継承]
14. (英) Prognosis (日) (読) [継承]
15. (英) Repressor Proteins (日) (読) [継承]
16. (英) Tumor Markers, Biological (日) (読) [継承]
17. (英) (日) 欧文論文 (読) [継承]
発行所 (推奨):
誌名 (必須): Oncology Reports (Ethnikon Hidryma Ereunōn (Greece))
(pISSN: 1021-335X, eISSN: 1791-2431)

ISSN (任意): 1791-2431
ISSN: 1021-335X (pISSN: 1021-335X, eISSN: 1791-2431)
Title: Oncology reports
Title(ISO): Oncol Rep
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 26 [継承]
(必須): 2 [継承]
(必須): 343 348 [継承]
都市 (任意):
年月日 (必須): 西暦 2011年 5月 20日 (平成 23年 5月 20日) [継承]
URL (任意):
DOI (任意): 10.3892/or.2011.1312    (→Scopusで検索) [継承]
PMID (任意): 21617866    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000292581500007 [継承]
Scopus (任意): 2-s2.0-79958218684 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.3892/or.2011.1312  (日)    [継承]
2.(英) Article.Affiliation: Department of Surgery, Institute of Health Biosciences, The University of Tokushima, Tokushima 770-8503, Japan.  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Jun Higashijima, Nobuhiro Kurita, Tomohiko Miyatani, Kouzou Yoshikawa, Shinya Morimoto, Masanori Nishioka, Takashi Iwata and Mitsuo Shimada : Expression of histone deacetylase 1 and metastasis-associated protein 1 as prognostic factors in colon cancer., Oncology Reports, Vol.26, No.2, 343-348, (発行所), (都市), May 2011.
欧文冊子 ● (種別) : Jun Higashijima, Nobuhiro Kurita, Tomohiko Miyatani, Kouzou Yoshikawa, Shinya Morimoto, Masanori Nishioka, Takashi Iwata and Mitsuo Shimada : Expression of histone deacetylase 1 and metastasis-associated protein 1 as prognostic factors in colon cancer., Oncology Reports, Vol.26, No.2, 343-348, (発行所), (都市), May 2011.

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