『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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組織 (推奨):
著者 (必須): 1.笠井 道之
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2. (英) Tanida Isei (日) (読)
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3. (英) Ueno Takashi (日) (読)
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4. (英) Kominami Eiki (日) (読)
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5. (英) Seki Sachiko (日) (読)
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6. (英) Ikeda Tohru (日) (読)
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7. (英) Mizuochi Toshiaki (日) (読)
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題名 (必須): (英) Autophagic compartments gain access to the MHC class II compartments in thymic epithelium.  (日)    [継承]
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要約 (任意): (英) The presentation of self-peptides in the context of MHC molecules by thymic epithelial cells (TECs) is essential for T cell repertoire selection in the thymus. However, the underlying mechanisms of this process have not been fully elucidated. To address whether autophagy, a catabolic process involving the degradation of a cell's components through the lysosomal machinery, intersects the MHC class II-restricted Ag presentation pathway in TECs, we investigated the colocalization of LC3, a peculiar autophagy marker molecule, with MHC class II compartments in in vitro-established TEC lines by immunofluorescence microscopy and Western blotting analyses. We found that in both cortical and medullary TEC lines, LC3 was colocalized with the H2-DM-positive lysosomal compartments, in which MHC class II plus class II-associated invariant chain peptides complexes are formed. Furthermore, our analysis of thymic cryosections from 1-day-old mice revealed that LC3 colocalizes with the H2-DM-positive compartments in TECs. These results strongly suggest that the cytoplasmic self-Ags gain access to the H2-DM-positive compartments via the autophagic process in the thymus.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigen Presentation (日) (読) [継承]
3. (英) Autophagy (日) (読) [継承]
4. (英) Blotting, Western (日) (読) [継承]
5. (英) Cell Line (日) (読) [継承]
6. (英) Epithelial Cells (日) (読) [継承]
7. (英) Histocompatibility Antigens Class II (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Mice, Inbred C57BL (日) (読) [継承]
10. (英) Microscopy, Fluorescence (日) (読) [継承]
11. (英) Microtubule-Associated Proteins (日) (読) [継承]
12. (英) Self Tolerance (日) (読) [継承]
13. (英) Thymus Gland (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
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(必須): 183 [継承]
(必須): 11 [継承]
(必須): 7278 7285 [継承]
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年月日 (必須): 西暦 2009年 11月 13日 (平成 21年 11月 13日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.0804087    (→Scopusで検索) [継承]
PMID (任意): 19915056    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Musashimurayama-shi, 4-7-1 Gakuen, Musashimurayama-shi, Tokyo 208-0011, Japan. kasai@nih.go.jp  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Michiyuki Kasai, Isei Tanida, Takashi Ueno, Eiki Kominami, Sachiko Seki, Tohru Ikeda and Toshiaki Mizuochi : Autophagic compartments gain access to the MHC class II compartments in thymic epithelium., The Journal of Immunology, Vol.183, No.11, 7278-7285, 2009.
欧文冊子 ● Michiyuki Kasai, Isei Tanida, Takashi Ueno, Eiki Kominami, Sachiko Seki, Tohru Ikeda and Toshiaki Mizuochi : Autophagic compartments gain access to the MHC class II compartments in thymic epithelium., The Journal of Immunology, Vol.183, No.11, 7278-7285, 2009.

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