『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=249866EID:249866, Map:0, LastModified:2014年3月7日(金) 15:55:29, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[松香 芳三], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Walwyn W M (日) (読)
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学籍番号 (推奨):
[継承]
2.松香 芳三 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.顎機能咬合再建学])
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Arai D (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Bloom D C (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Lam H (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Tran C (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Spigelman I (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Maidment N T (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy.  (日)    [継承]
副題 (任意):
要約 (任意): (英) A previous phase III clinical trial failed to show significant therapeutic benefit of repeated subcutaneous nerve growth factor (NGF) administration in the treatment of diabetic neuropathy. Animal studies have since shown that site-specific viral-mediated expression of NGF in the lumbar dorsal root ganglia prevents peripheral nerve dysfunction associated with chemically induced neuropathy. Using a Herpes simplex virus expression vector, we have investigated the effect of localized NGF expression in a genetic mouse model of progressive diabetic neuropathy, the +/+ Leprdb mouse. We found that site-specific delivery of NGF initially delayed the appearance of hypoalgesia, assessed by the Hargreaves test, by 1 month and effectively attenuated this deficit for 2 months over the approximately 10 months normal life-span of these animals. Once the disease progressed into its more severe stages, NGF, although still capable of altering the electrophysiological profile of the sensory A- and C-fibers and influencing the expression of p75 and substance P in the dorsal root ganglia, could no longer maintain normal nociception. These data suggest that maximal therapeutic benefit in future NGF-based gene therapy trials will be gained from early applications of such viral-mediated neurotrophin delivery.  (日)    [継承]
キーワード (推奨): 1. (英) Action Potentials (日) (読) [継承]
2. (英) Age Factors (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Behavior, Animal (日) (読) [継承]
5. (英) Blotting, Northern (日) (読) [継承]
6. (英) Cell Count (日) (読) [継承]
7. (英) Diabetic Nephropathies (日) (読) [継承]
8. (英) Disease Models, Animal (日) (読) [継承]
9. (英) Dose-Response Relationship, Radiation (日) (読) [継承]
10. (英) Electric Stimulation (日) (読) [継承]
11. (英) Ganglia, Spinal (日) (読) [継承]
12.遺伝子治療 (gene therapy) [継承]
13. (英) Genetic Vectors (日) (読) [継承]
14.免疫組織化学 (immunohistochemistry) [継承]
15. (英) Male (日) (読) [継承]
16. (英) Mice (日) (読) [継承]
17. (英) Mice, Inbred C57BL (日) (読) [継承]
18. (英) Nerve Fibers (日) (読) [継承]
19. (英) Nerve Growth Factors (日) (読) [継承]
20. (英) Pain Measurement (日) (読) [継承]
21. (英) RNA, Messenger (日) (読) [継承]
22. (英) Reaction Time (日) (読) [継承]
23. (英) Receptor, Nerve Growth Factor (日) (読) [継承]
24. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
25. (英) Simplexvirus (日) (読) [継承]
26. (英) Substance P (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Experimental Neurology ([Elsevier])
(pISSN: 0014-4886, eISSN: 1090-2430)

ISSN (任意): 0014-4886
ISSN: 0014-4886 (pISSN: 0014-4886, eISSN: 1090-2430)
Title: Experimental neurology
Title(ISO): Exp Neurol
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2006年 1月 20日 (平成 18年 1月 20日) [継承]
URL (任意):
DOI (任意): 10.1016/j.expneurol.2005.12.006    (→Scopusで検索) [継承]
PMID (任意): 16427624    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000235747000027 [継承]
Scopus (任意): 2-s2.0-32644433171 [継承]
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備考 (任意): 1.(英) Affiliation: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA 90024-1759, USA. wwalwyn@ucla.edu  (日)    [継承]
2.(英) PublicationType: Comparative Study  (日)    [継承]
3.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● M W Walwyn, Yoshizo Matsuka, D Arai, C D Bloom, H Lam, C Tran, I Spigelman and T N Maidment : HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy., Experimental Neurology, Vol.198, No.1, 260-270, 2006.
欧文冊子 ● M W Walwyn, Yoshizo Matsuka, D Arai, C D Bloom, H Lam, C Tran, I Spigelman and T N Maidment : HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy., Experimental Neurology, Vol.198, No.1, 260-270, 2006.

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