| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kurimoto Shin-ichiro (日) 栗本 慎一郎 (読)
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| 2. | 柏田 良樹
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| 3. | (英) Morris-Natschke L. Susan (日) (読)
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| 4. | (英) Lee Kuo-Hsiung (日) (読)
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| 5. | 高石 喜久 ([徳島大学.デザイン型AI教育研究センター])
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| ○題名 (必須): | □ | (英) Dyscusins AC, Three New Steroids From the Leaves of Dysoxylum cumingianum. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Three new steroids dyscusins A-C (1-3), including a stigmastane-type sterol and two pregnanes, together with two known steroids were isolated from the leaves of Dysoxylum cumingianum (Meliaceae). Their structures were elucidated on the basis of extensive spectroscopic analyses. In a cytotoxicity assay, compound 1 showed ten-fold enhanced cytotoxicity against multi-drug resistant cancer cells (KB-C2) in the presence of 2.5 µM colchicine as compared with the absence of colchicine. This notable finding indicated that 1 possessed a multi-drug resistant reversal effect. (日)
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| ○キーワード (推奨): | 1. | (英) Antineoplastic Agents, Phytogenic (日) (読)
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| 2. | (英) Cell Line, Tumor (日) (読)
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| 3. | (英) Colchicine (日) (読)
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| 4. | (英) Drug Screening Assays, Antitumor (日) (読)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Meliaceae (日) (読)
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| 7. | (英) Molecular Structure (日) (読)
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| 8. | (英) Phytotherapy (日) (読)
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| 9. | (英) Plant Leaves (日) (読)
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| 10. | (英) Pregnanes (日) (読)
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| 11. | (英) Steroids (日) (読)
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| 12. | (英) Sterols (日) (読)
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| 13. | (英) Tubulin Modulators (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Chemical & Pharmaceutical Bulletin ([日本薬学会])
(pISSN: 0009-2363, eISSN: 1347-5223)
| ○ISSN (任意): | □ | 1347-5223
ISSN: 0009-2363
(pISSN: 0009-2363, eISSN: 1347-5223) Title: Chemical & pharmaceutical bulletinTitle(ISO): Chem Pharm Bull (Tokyo)Supplier: 公益社団法人日本薬学会Publisher: Pharmaceutical Society of Japan (NLM Catalog)
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| ○巻 (必須): | □ | 59
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| ○号 (必須): | □ | 10
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| ○頁 (必須): | □ | 1303 1306
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2011年 10月 初日 (平成 23年 10月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1248/cpb.59.1303 (→Scopusで検索)
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| ○PMID (任意): | □ | 21963644 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000295391200017
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| ○Scopus (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural (日)
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