| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | 柏田 良樹
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| 2. | (英) Kazuya Nishimura (日) 西村 和也 (読)
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| 3. | (英) Shin-ichiro Kurimoto (日) 栗本 慎一郎 (読)
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| 4. | 高石 喜久 ([徳島大学.デザイン型AI教育研究センター])
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| ○題名 (必須): | □ | (英) New 29-nor-cycloartanes with a 3,4-seco- and a novel 2,3-seco-structure from the leaves of Sinocalycanthus chinensis. (日)
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| ○要約 (任意): | □ | (英) Eight new triterpenoids, including sinocalycanchinensins A-E (1-5) with a 3,4-seco-29-nor-cycloartane skeleton, sinocalycanchinensin F (6) possessing a novel 2,3-seco-29-nor-cycloartane skeleton, and 29-nor-cycloartanes, sinocalycanchinensins G and H (7 and 8), have been isolated from the leaves of Sinocalycanthus chinensis. Their structures were elucidated on the basis of spectroscopic examinations. The cytotoxicities of the isolated new triterpenes against a panel of human cancer cell lines, including multi-drug resistant (MDR) cancer cell lines, were also evaluated. Compound 5 demonstrated enhanced cytotoxicity against MDR KB cells in the presence of colchicine, although all the compounds showed moderate or no cytotoxicities. (日)
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| ○キーワード (推奨): | 1. | (英) Calycanthaceae (日) (読)
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| 2. | (英) Cell Line, Tumor (日) (読)
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| 3. | (英) Drug Screening Assays, Antitumor (日) (読)
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| 4. | (英) Humans (日) (読)
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| 5. | (英) Magnetic Resonance Spectroscopy (日) (読)
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| 6. | (英) Molecular Conformation (日) (読)
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| 7. | (英) Plant Leaves (日) (読)
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| 8. | (英) Triterpenes (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Bioorganic & Medicinal Chemistry ([Elsevier Science])
(pISSN: 0968-0896, eISSN: 1464-3391)
| ○ISSN (任意): | □ | 1464-3391
ISSN: 0968-0896
(pISSN: 0968-0896, eISSN: 1464-3391) Title: Bioorganic & medicinal chemistryTitle(ISO): Bioorg Med ChemPublisher: Elsevier Ltd (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login])
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| ○巻 (必須): | □ | 19
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | 2790 2796
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2011年 5月 初日 (平成 23年 5月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bmc.2011.03.055 (→Scopusで検索)
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| ○PMID (任意): | □ | 21493075 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Graduate School of Pharmaceutical Sciences, University of Tokushima, 1-78 Shomachi, Tokushima 770-8505, Japan. kasiwada@ph.tokushima-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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